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Synthesis, Characterization and Evaluation of Topical Antiinflammatory Activity of Dimethyl 4-Oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate
Corresponding Author(s) : Mazin Nadhim Mousa Al Ugla
Asian Journal of Chemistry,
Vol. 25 No. 5 (2013): Vol 25 Issue 5
Abstract
An attempt was made to synthesize a topical preparation of an active compound that has a potent antiinflammatory activity. Dimethyl 4-oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate (II) was prepared by aldol condensation of benzaldehyde and acetone followed by Michael addition of dimethyl malonate. The optimum concentration of the compound was determined by comparing the antiinflammatory effect of ointment preparations at different concentrations. The antiinflammatory effects were studied by using carrageenan-induced paw edema method in rat and xylene induced rat ear edema. Good effect was observed with ointment containing 4 % and 5 % of the compound II concentration. The results showed that the drug had an obvious antiinflammatory effect as an external preparation and the activity is comparable to that of the standard ointment.
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- International Journal of PharmTech Research, Evaluation of Antiinflammatory Activity and Potency of Herbal Formulation Consists of Different Proportions of Curcuma longa and Boswellia serrata by Using Cotton Pellet granuloma and Xylene Induced Mice Ear Edema Model, vol. 2, no.3, pp. 1855-1860, July-Sept (2010).
- K. Kyuki, Nippon Yakurigaku Zasshi, 79, 461 (1982).
- J.H. Vaile and P. Davis, Drugs, 56, 783 (1998).
- S. Handayani and I.S. Arty, J. Phys. Sci., 19, 61 (2008).
- D. Giles, R. Karkib, F.R. Sheeba, D.P. Venkatesh and P.M. Gurubasavarajaswamy, J. Pharm. Sci. Res., 3, 1253 (2011).
- K. Morteza-Semnani, M. Saeedi and M. Hamidian, Fitoterapia, 75, 123 (2004).
- M.A. Dkhil, A.S. Abdel-Baki, S. Al-Quraishi and M. Al-Khalifa, Afr. J. Pharm. Pharmacol., 4, 115 (2010).
- P. Garcia-Pastor, A. Randazzo, L. Gomez-Paloma, M.J. Alcaraz and M. Paya, J. Pharmacol. Exp. Ther., 289, 166 (1999).
- F. Sharififar, P. Khazaeli and N. Alli, Iran. J. Pharm. Sci., 5, 157 (2009).
- M. Gabor, Methods Mol. Biol., 225, 129 (2003)
References
International Journal of PharmTech Research, Evaluation of Antiinflammatory Activity and Potency of Herbal Formulation Consists of Different Proportions of Curcuma longa and Boswellia serrata by Using Cotton Pellet granuloma and Xylene Induced Mice Ear Edema Model, vol. 2, no.3, pp. 1855-1860, July-Sept (2010).
K. Kyuki, Nippon Yakurigaku Zasshi, 79, 461 (1982).
J.H. Vaile and P. Davis, Drugs, 56, 783 (1998).
S. Handayani and I.S. Arty, J. Phys. Sci., 19, 61 (2008).
D. Giles, R. Karkib, F.R. Sheeba, D.P. Venkatesh and P.M. Gurubasavarajaswamy, J. Pharm. Sci. Res., 3, 1253 (2011).
K. Morteza-Semnani, M. Saeedi and M. Hamidian, Fitoterapia, 75, 123 (2004).
M.A. Dkhil, A.S. Abdel-Baki, S. Al-Quraishi and M. Al-Khalifa, Afr. J. Pharm. Pharmacol., 4, 115 (2010).
P. Garcia-Pastor, A. Randazzo, L. Gomez-Paloma, M.J. Alcaraz and M. Paya, J. Pharmacol. Exp. Ther., 289, 166 (1999).
F. Sharififar, P. Khazaeli and N. Alli, Iran. J. Pharm. Sci., 5, 157 (2009).
M. Gabor, Methods Mol. Biol., 225, 129 (2003)