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Vol. 25 No. 5 (2013): Vol 25 Issue 5

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New Saponins from Timosaponin BIII by Acid Hydrolysis

https://doi.org/10.14233/ajchem.2013.13428
Zhiyu Liu
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, P.R. China ; Harbin University of Commerce, Harbin 150076, P.R. China
Weixin Jiang
Harbin University of Commerce, Harbin 150076, P.R. China
Bin Wu
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, P.R. China
Chenggang Huang
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, P.R. China

Corresponding Author(s) : Bin Wu

wubin1031@hotmail.com

Asian Journal of Chemistry, Vol. 25 No. 5 (2013): Vol 25 Issue 5

Abstract

Timosaponin BIII (TBIII), a saponin isolated from the rhizome of Anemarrhena asphodeloides, exhibited potent antidepressive and anxiolytic activities in depressed mice. After administration of TBIII in rats, two main metabolites had been detected in the brain tissue, which had similar aglycone with TBIII and formed by elimination of two hexose moieties. In this study, we had hydrolyzed TBIII by some means and obtained 4 artificial steroidal saponins (three novel steroidal saponins: timosaponin BIII-a, timosaponin BIII-b, timosaponin BIII-c; and a known steroidal saponin: timosaponin BII-b) by the dilute-acid hydrolysis. Their structures were verified by means of mass spectrometry and nuclear magnetic resonance (NMR) spectral analyses.

Keywords

Rhizoma anemarrhenae Steroidal saponin Timosaponin BIII Acid hydrolysis NMR
Liu, Z., Jiang, W., Wu, B., & Huang, C. (2012). New Saponins from Timosaponin BIII by Acid Hydrolysis. Asian Journal of Chemistry, 25(5), 2503–2505. https://doi.org/10.14233/ajchem.2013.13428
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