Copyright (c) 2013 AJC
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Determination of Protocatechuic Aldehyde in Danshen Injection by Flow Injection Chemiluminescence
Corresponding Author(s) : Pingping Zhang
Asian Journal of Chemistry,
Vol. 25 No. 4 (2013): Vol 25 Issue 4
Abstract
A novel chemiluminescence system for determination of protocatechuic aldehyde with flow injection analysis is described. It is based on the chemiluminescence reaction of potassium ferricyanide and luminol in sodium hydroxide medium. The optimized experimental conditions were evaluated. Under optimum conditions, calibration curve over the range of 1.0-50 mg L-1 was obtained (r = 0.9992). The detection limit of this method was 0.2 mg L-1. The relative standard deviation was 3.4 % for 20 mg L-1 protocatechuic aldehyde. The method has been applied to the determination of studied protocatechuic aldehyde in Danshen injection with a satisfactory result.
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References
L. Zhou, Z. Zuo and M.S. Chow, J. Clin. Pharmacol., 45, 1345 (2005).
H.J. Chae, S.W. Chae, D.H. Yun, K.S. Keum, S.K. Yoo and H.R. Kim, Immunopharmacol. Immunotoxicol., 26, 135 (2004).
L. Wu, H. Qiao, Y. Li and L. Li, Phytomedicine, 14, 652 (2007).
Z. Zhou, Y. Liu, A.D. Miao and S.Q. Wang, Eur. J. Pharmacol., 513, 1 (2005).
Z. Zhou, Y. Zhang, X.R. Ding, S.H. Chen, J. Yang, X.J. Wang, G.L. Jia, H.S. Chen, X.C. Bo and S.Q. Wang, Antiviral Res., 74, 59 (2007).
J.W. Gao, T. Yamane, H. Maita, S. Ishikawa, S.M. Iguchi-Ariga, X.P. Pu and H. Ariga, J. Pharmacol. Sci., 115, 36 (2011).
H.X. Liu, Y. Liu, J.W. Zhang, W. Li, H.T. Liu and L. Yang, Drug Metab. Dispos., 36, 1562 (2008).
L. Zhang, X. G. Xu, Y.Z. Shi, W.H.Shan and B.M.Xu, Chin. J. Pharm. Anal., 17, 253 (1997).
Y.L. Pan, L. Zhang and G.N. Chen, Analyst, 126, 1519 (2001).
S.N. Zhang, H.L. Yang, Z.Q. Liu, J.P. Liu, W. Li, X.S. Liu and H.B. Qu, Chin. J. Pharm. Anal., 29, 192 (2009).
M. Xu, Z.C. Zhang, G. Fu, S.F. Sun, J.H. Sun, M. Yang, A.H. Liu, J. Han and D.A. Guo, J. Chromatogr. B, 856, 100 (2007).
J. Xie, Y. Zhang, D. Kong and M. Rexit, J. Food Compos. Anal., 24, 1069 (2011).
Chemical Industry Press: Chemiluminescence-basic principles and applications, J.M. Lin, Beijing, pp. 42/16-42/17 (2004)