Antioxidant Activity of Arctium lappa L. and Its Effect on Biochemical Parameters in Exercised Rats

Chi-Ting Horng; Ming-Ling Tsai; Chao-Wen Hsueh; Shun-Yuan Hsu; Hui-Yun Wang; Fu-An Chen

doi:10.14233/ajchem.2013.13271

Issue

Vol. 25 No. 4 (2013): Vol 25 Issue 4

Issue Published : November 1, 2012

This work is licensed under a Creative Commons Attribution 4.0 International License.

Antioxidant Activity of Arctium lappa L. and Its Effect on Biochemical Parameters in Exercised Rats

https://doi.org/10.14233/ajchem.2013.13271

Chi-Ting Horng

Department of Ophthalmology, Kaohsiung Armed Force General Hospital, Kaohsiung, Taiwan ; Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan

Ming-Ling Tsai

Department of ophthalmology, Tri-Service General Hospital, Taipei, Taiwan

Chao-Wen Hsueh

Department of Medicine, Kaohsiung Armed Force General Hospital, Kaohsiung, Taiwan

Shun-Yuan Hsu

Department of Orthopedics, Kaohsiung Armed Force General Hospital, Kaohsiung, Taiwan

Hui-Yun Wang

Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan

Fu-An Chen

Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan

Corresponding Author(s) : Fu-An Chen

fachen@mail.tajen.edu.tw

Asian Journal of Chemistry, Vol. 25 No. 4 (2013): Vol 25 Issue 4
Article Published : November 1, 2012

Abstract

The root of the medicinal plant locally known as burdock (Arctium lappa L.) has long been cultivated as a popular vegetable across Taiwan for human consumption and traditional medicine. The present study is to investigate the antioxidant activity of Arctium lappa and its effect on biochemical parameters in exercised rats. The extract of root of burdock was prepared and then subjected to analysis of polyphenols and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity. Sprague-Dawley rats were divided into five groups including control (fed with drinking water) and three groups of different doses of burdock extracts (BE). After eight weeks, an exhaustive exercise test on a treadmill and the measurement of biochemical parameters related to fatigue were carried out. The results revealed that burdock extract was able to extend significantly the endurance time of treadmill running to exhaustion, as well as decreasing the blood lactate and serum urea nitrogen contents with comparison to that of control group. Malondialdehyde level of rats in burdock extract treated groups were significantly decreased, while superoxide dilmutase (SOD) were significantly increased compared with that of control group. The results shows that Arctium lappa is capable of ameliorating biochemical parameters related to fatigue in the exercised rat model that could be associated with the antioxidant polyphenols with free radical scavenging activities.

Keywords

Arctium lappa Burdock Antioxidant Biochemical parameters Antifatigue

Horng, C.-T., Tsai, M.-L., Hsueh, C.-W., Hsu, S.-Y., Wang, H.-Y., & Chen, F.-A. (2012). Antioxidant Activity of Arctium lappa L. and Its Effect on Biochemical Parameters in Exercised Rats. Asian Journal of Chemistry, 25(4), 1970–1974. https://doi.org/10.14233/ajchem.2013.13271

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References

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D.P. Maclaren, H. Gibson, M. Parry-Billings and R.H. Edwards, Exerc. Sport Sci. Rev., 17, 29 (1989).
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Y.J. Ding, K.J. Tang, F.L. Li and Q.L. Hu, Afr. J. Agric. Res., 5, 707 (2010).
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References

H. Gibson and R.H.T. Edwards, Sports Med., 2, 120 (1985).

D.P. Maclaren, H. Gibson, M. Parry-Billings and R.H. Edwards, Exerc. Sport Sci. Rev., 17, 29 (1989).

X. Shan, J. Zhou, T. Ma and Q. Chai, Int. J. Mol. Sci., 12, 1081 (2011).

H.H. Tian, W.S. Ong and C.L. Tan, Singapore Med. J., 50, 165 (2009).

L. Ma and D.L. Cai, Zhong Xi Yi Jie He Xue Bao., 4, 541 (2006).

C.M. Han, Agric. World, 145, 55 (1995).

L.W. Chow, S.J. Wang and P.D. Duh, Food Sci., 24, 195 (1997).

K. Morita, Y. Nishijima and T. Kada, Mutat. Res., 129, 25 (1984).

C.C. Lin, J.M. Lin, J.J. Yang, S.C. Chuang and T. Ujiie, Am. J. Chin. Med., 24, 127 (1996).

P.D. Duh, J. Am. Oil Chem. Soc., 75, 455 (1998).

F.A. Chen, A.B. Wu and C.Y. Chen, Food Chem., 86, 479 (2004).

Z. Lou, H. Wang, J. Li, S. Chen, S. Zhu, C. Ma and Z. Wang, J. Food Sci., 75, C413 (2010).

S.C. Lin, T.C. Chung, C.C. Lin, T.H. Ueng, Y.H. Lin, S.Y. Lin and L.Y. Wang, Am. J. Chin. Med., 28, 163 (2000).

S.C. Lin, C.H. Lin, C.C. Lin, Y.H. Lin, C.F. Chen, I.C. Chen and L.Y. Wang, J. Biomed. Sci., 9, 401 (2002).

F.A. Chen, S.C. Lee., H.R. Chao, W.C. Fu, M.C. Hsu, C.T. Horng, C.C. Wang, H. Matsui and G. Agoramoorthy, Asian J. Chem., 21, 3015 (2009).

A.C. Dos Santos, C.H. Baggio, C.S. Freitas, J. Lepieszynski, B. Mayer, A. Twardowschy, F.C. Missau, E.P. Dos Santos, M.G. Pizzolatti and M.C. Marques, J. Pharm. Pharmacol., 60, 795 (2008).

C.C. Lin, J.M. Lin, J.J. Yang, S.C. Chuang and T. Ujiie, Am. J. Chin. Med., 24, 127 (1996).

P.S. Negi, G.K. Jayaprakasha and B.S. Jena, Food Chem., 80, 393 (2003).

F.A. Chen, S.C. Lee, H.R. Chao, W.C. Fu, M.C. Hsu, C.T. Horng, C.C. Wang, H. Matsui and G. Agoramoorthy, Asian J. Chem., 21, 3015 (2009).

F.A. Chen, A.B. Wu, P. Shieh, D.H. Kuo and C.Y. Hsieh, Food Chem., 94, 14 (2006).

T.G. Bedford, C.M. Tipton, N.C Wilson, R.A. Oppliger and C.V. Gisolfi, J. Appl. Physiol., 47, 1278 (1979).

D. Katiyar, B. Singh and C. Haldar, Eur. J. Pharm. Sci., 44, 534 (2001).

H. Ohkawa, N. Ohishi and K. Yagi, Anal. Biochem., 95, 351 (1979).

H.I. Lo, D.T. Amabel, C.L. Tan, S.W. Wang and M.C. Hsu,Chin. J. Physiol., 48, 187 (2005).

Y.J. Ding, K.J. Tang, F.L. Li and Q.L. Hu, Afr. J. Agric. Res., 5, 707 (2010).

D.P. Maclaren, H. Gibson, M. Parry-Billings and R.H. Edwards, Exerc. Sport Sci. Rev., 17, 29 (1989).

A. Kasperska-Zajac, Z. Brzoza, B. Rogala, R. Polaniak and E. Birkner, J. Investig. Allergol. Clin. Immunol., 18, 372 (2008).

F. Yu, S. Lu, F. Yu, S. Feng, P.M. McGuire, R. Li and R. Wang, Can. J. Physiol. Pharmacol., 84, 1071 (2006).

L. Fan, F. Zhai, D. Shi, X. Qiao, X. Fu and H. Li, Sci. Res. Essays, 6, 2624 (2011).

F.S. Predes, A.L. Ruiz, J.E. Carvalho, M.A. Foglio and H. Dolder, BMC Compl. Alternative Med., 11, 25 (2011).

B. Tharakan, M. Dhanasekaran and B.V. Manyam, Phytother Res., 19, 669 (2005).

E.A. Newsholme, E. Blomstrand and B. Ekblom, Br. Med. Bull., 48, 477 (1992).

C.C. Huang, T.J. Lin, Y.F. Lu, C.C. Chen, C.Y. Huang and W.T. Lin, Chin. J. Physiol., 52, 306 (2009).

Issue

Vol. 25 No. 4 (2013): Vol 25 Issue 4

Antioxidant Activity of Arctium lappa L. and Its Effect on Biochemical Parameters in Exercised Rats

Corresponding Author(s) : Fu-An Chen

Abstract

Keywords

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