Antioxidative Coumarins from the Roots of Ferulago subvelutina&nbsp;

M. Naseri; H.R. Monsef-Esfehani; S. Saeidnia; D. Dastan; A.R. Gohari

doi:10.14233/ajchem.2013.13208

Issue

Vol. 25 No. 4 (2013): Vol 25 Issue 4

Issue Published : November 1, 2012

This work is licensed under a Creative Commons Attribution 4.0 International License.

Antioxidative Coumarins from the Roots of Ferulago subvelutina

https://doi.org/10.14233/ajchem.2013.13208

M. Naseri

Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

H.R. Monsef-Esfehani

Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

S. Saeidnia

Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

D. Dastan

Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran

A.R. Gohari

Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Corresponding Author(s) : A.R. Gohari

goharii_a@tums.ac.ir

Asian Journal of Chemistry, Vol. 25 No. 4 (2013): Vol 25 Issue 4
Article Published : November 1, 2012

Abstract

From the ethyl acetate extract of the roots of Ferulago subvelutina (Apiaceae) six coumarins, osthol (1), oxypeucedanin (2), xanthotoxin (3), isoimperatorin (4), oxypeucedanin hydrate (5), meranzine hydrate (6) and one sterol, b-sitosteryl linoleate (7), were isolated by silica gel column chromatography and identified by spectroscopic methods. Antioxidant activities of the isolated compounds were tested by the DPPH radical scavenging assay. Compounds exhibited moderate antioxidant activities. DPPH scavenging abilities of compounds were lower than that of synthetic antioxidant tert-butyl hydroxytoluene (BHT) (IC₅₀ = 27 μg/mL) in the order BHT > oxypeucedanin hydrate > meranzin hydrate > oxypeucedanin > isoimperaturin > xanthotoxin > osthole.

Keywords

Ferulago subvelutina Apiaceae Coumarin Osthol Oxypeucedanin Xanthotoxin Isoimperatorin Oxypeucedanin hydrate Meranzine hydrate

Naseri, M., Monsef-Esfehani, H., Saeidnia, S., Dastan, D., & Gohari, A. (2012). Antioxidative Coumarins from the Roots of Ferulago subvelutina . Asian Journal of Chemistry, 25(4), 1875–1878. https://doi.org/10.14233/ajchem.2013.13208

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References

K.H. Rechinger, I.C. Hedge and J.M. Lamond, Flora Iranica, 162, 427 (1987).

A. Rustaiyan, S. Sedaghat, K. Larijani, M. Khossravi and S. Masoudi, J. Essent. Oil Res., 14, 447 (2002).

F. Sefidkon and R. Omidbaigi, J. Essent. Oil Bearing Plants, 7, 60 (2004).

S. Rezazadeh, D. Yazdani and S. Shahnazi, J. Med. Plants, 2, 49 (2003).

F. Chalabian,A. Monfared, K. Larijani and S. Saldoosi, J. Med. Aromat. Plants, 22, 146 (2006).

P. Molyneux, J. Sci. Technol., 26, 211 (2004).

P. Zhou, Y. Takaishi, H. Duan, B. Chen, G. Honda, M. Itoh, Y. Takeda, O.K. Kodzhimatov and K.H. Lee, Phytochemistry, 53, 689 (2000).

S. Harkar, T.K. Razdan and E.S. Waight, Phytochemistry, 23, 419 (1984).

T. Masuda, M. Takasugi and M. Anetai, Phytochemistry, 47, 13 (1998).

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B. Jimenez, M.C. Grande, J. Anaya and P. Torres, Phytochemistry, 53, 1025 (2000).

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