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Vol. 25 No. 4 (2013): Vol 25 Issue 4

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Synthesis, Spectral Characterization and Biological Evaluation of Schiff Base Transition Metal Complexes Derived from Ampicillin with D-Glucose

https://doi.org/10.14233/ajchem.2013.13413
Narjis Naz
Department of Chemistry, Lahore College for Women University, Lahore-54000, Pakistan
Shakera Khatoon
Gujranwala Institute of Nuclear Medicine and Radiotherap, Gujranwala, Pakistan
Humayun Ajaz
Department of Chemistry, University of Engineering & Technology, Lahore-54000, Pakistan
Zubi Sadiq
Department of Chemistry, Lahore College for Women University, Lahore-54000, Pakistan
Muhammad Zafar Iqbal
Department of Chemistry, Lahore College for Women University, Lahore-54000, Pakistan

Corresponding Author(s) : Narjis Naz

narjis107@gmail.com

Asian Journal of Chemistry, Vol. 25 No. 4 (2013): Vol 25 Issue 4

Abstract

Schiff base metal complexes derived from ampicillin with D-glucose and Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) have been successfully synthesized. Elemental analysis, molar conductance, magnetic susceptibility, thermal analysis along with electronic and infrared spectral studies determined the structural assessment of complexes that formulated as ML2 type. All the compounds under investigation were screened for antimicrobial appraisal to evaluate the effect of derivatization and metals on antibiotic. It evidenced that all the schiff base metal complexes are more potential bactericidal agents as compared to parent ampicillin.

Keywords

Ampicillin Coordination complexes Biological assay D-Glucose Schiff base complexes
Naz, N., Khatoon, S., Ajaz, H., Sadiq, Z., & Zafar Iqbal, M. (2012). Synthesis, Spectral Characterization and Biological Evaluation of Schiff Base Transition Metal Complexes Derived from Ampicillin with D-Glucose. Asian Journal of Chemistry, 25(4), 2239–2242. https://doi.org/10.14233/ajchem.2013.13413
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