Copyright (c) 2013 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Heme Polymerization Inhibitory Activities of Xanthone from G. parvifolia (Miq) Miq Stem Bark as an Antimalarial Agent
Corresponding Author(s) : Syamsudin
Asian Journal of Chemistry,
Vol. 25 No. 3 (2013): Vol 25 Issue 3
Abstract
A study had been conducted to isolate, to identify and to test heme polymerization inhibitory activities of G. parvifolia (Miq)Miq stem bark active compounds with antimalarial properties. UV, IR, RMI 1D (1H NMR and 13C NMR) and RMI 2D (COSY, HMQC and HMBC) and mass spectra were used for identification. Heme polymerization inhibitory activity assay was conducted in vitro by measuring b-hematin formation using ELISA reader. The study revealed that the active isolates derived from xanthone compounds, 1,3,6-trihydroxy-2-(3-methylbut-2-enyl)-7-methoxy-8-(3-methylbut-2-enyl)xanthen-9-on. HPIA assay showed that the compounds acted by inhibiting weak heme polymerization activities.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- World Health Organization, J. Epid. Week, 72, 269 (1997).
- Department Kesehatan Republik Indonesia. Standard Pengawasan Program Bidang Kesehatan Pemberantasan Penyakit Malaria, 5 (2001).
- H.M. Abednego and T. Suroso, National Seminar on Mosquito-borne Diseases by Molecular Approaches. Pusat Kedokteran Tropis, Fakultas Kedokteran UGM, Yogyakarta, Indonesia (1998).
- Mustofa, Majalah Obat Trad., 8, 8 (2003).
- J.Y. Xu, Y.H. Lai, Z. Imiyabir and S.H. Goh, J. Nat. Prod., 64, 1191 (2001).
- M.V. Ignatushchenko, R.W. Winter and M. Riscoe, Am. J. Trop. Med. Hyg., 62, 77 (2000).
- P.J. Rosenthal, J. Exp. Biol., 206, 3735 (2005).
- T.J. Egan, Drug Design Rev. Online, 1, 93 (2004).
- B.L. Tekwani and L.A. Walker, Comb. Chem. and High Troughput Screening, 8, 63 (2005).
- J.C.P. Steele, R.J. Philips, M.S. Simmonds, D.C. Warhurst and D.J. Meyer, J. Antimicrob. Chemother., 50, 25 (2005).
References
World Health Organization, J. Epid. Week, 72, 269 (1997).
Department Kesehatan Republik Indonesia. Standard Pengawasan Program Bidang Kesehatan Pemberantasan Penyakit Malaria, 5 (2001).
H.M. Abednego and T. Suroso, National Seminar on Mosquito-borne Diseases by Molecular Approaches. Pusat Kedokteran Tropis, Fakultas Kedokteran UGM, Yogyakarta, Indonesia (1998).
Mustofa, Majalah Obat Trad., 8, 8 (2003).
J.Y. Xu, Y.H. Lai, Z. Imiyabir and S.H. Goh, J. Nat. Prod., 64, 1191 (2001).
M.V. Ignatushchenko, R.W. Winter and M. Riscoe, Am. J. Trop. Med. Hyg., 62, 77 (2000).
P.J. Rosenthal, J. Exp. Biol., 206, 3735 (2005).
T.J. Egan, Drug Design Rev. Online, 1, 93 (2004).
B.L. Tekwani and L.A. Walker, Comb. Chem. and High Troughput Screening, 8, 63 (2005).
J.C.P. Steele, R.J. Philips, M.S. Simmonds, D.C. Warhurst and D.J. Meyer, J. Antimicrob. Chemother., 50, 25 (2005).