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Synthesis of Super Absorbent Hydrogels with Using Releasing Drug
Corresponding Author(s) : Fatemeh Soleimani
Asian Journal of Chemistry,
Vol. 25 No. 2 (2013): Vol 25 Issue 2
Abstract
In this work, a novel family of pH-responsive polymeric hydrogel based on collagen was prepared for realesing drug. Acrylic monomers, acrylic acid and itaconic acid were simultaneously graft copolymerized onto collagen backbones by a free radical polymerization technique using ammonium persulfate as initiator and methylene bisacrylamide as a crosslinker. Hydrogel formation was confirmed by FTIR spectroscopy. Thermogravimetric analysis showed the thermal stabilities of the hydrogels. Results from scanning electron microscopy also showed a porous structure with smooth surface morphology of the hydrogel the super absorbent hydrogels exhibited high sensitivity to pH, so that, several swelling changes of the hydrogel were observed in pH variations of a wide pH range (1-13).
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- B. Marandi, G. Mahdavinia and G.R. Ghafary, J. Appl. Polym. Sci., 120, 1170 (2011).
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- L.Y. Chu, T. Yamaguchi and S.A. Nakao, Adv. Mater., 14, 386 (2002).
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References
B. Marandi, G. Mahdavinia and G.R. Ghafary, J. Appl. Polym. Sci., 120, 1170 (2011).
M.C. Branco, D.J. Pochan, N.J. Wagner and J.P. Schneider, Biomaterials, 31, 9527 (2010).
F.L. Buchholz and A.T. Graham, Modern Superabsorbent Polymer Technology, New York: Wiley (1997).
H. Cheng, J.L. Zhu, Y.X. Sun, S.X. Cheng, X.Z. Zhang and R.X. Zhuo, Bioconjug. Chem., 19, 1368 (2008).
L.Y. Chu, J.W. Kim, R.K. Shah and D.A. Weitz, Adv. Funct. Mater., 17, 3499 (2007).
L.Y. Chu, T. Yamaguchi and S.A. Nakao, Adv. Mater., 14, 386 (2002).
V. Crescenzi, L. Cornelio, C. Di Meo, S. Nardecchia and R. Lamanna, Biomacromolecules, 8, 1844 (2007).
D.T. Eddington and D.J. Beebe, Adv. Drug Deliv. Rev., 56, 199 (2004).
M. Hamidi,A. Azadi and P. Rafiei, Adv. Drug Deliv. Rev., 60, 1638 (2008).
S. Hua and A. Wang, Carbohydr. Polym., 75, 79 (2009).
S. Kakinoki, T. Taguchi, H. Saito, J. Tanaka and T. Tateishi,Eur. J. Pharm. Biol., 66, 383 (2007).