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Vol. 25 No. 2 (2013): Vol 25 Issue 2

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Synthesis and Characterization of Organotin(IV) Complexes Derivatives of Methyl- and Nitro- Substituted Monocarboxylic Acid: Preliminary in vitro Antibacterial Screening Activity

https://doi.org/10.14233/ajchem.2013.13292
Yip-Foo Win
Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia ; School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden Penang, Pulau Pinang, Malaysia
Chen-Shang Choong
Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia
Sie-Tiong Ha
Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia
Siang-Guan Teoh
School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden Penang, Pulau Pinang, Malaysia
Naser Eltaher Eltayeb
School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden Penang, Pulau Pinang, Malaysia ; Department of Chemistry, Faculty of Pure and Applied Sciences, International University of Africa, Khartoum, Sudan

Corresponding Author(s) : Yip-Foo Win

williamyfw@yahoo.com

Asian Journal of Chemistry, Vol. 25 No. 2 (2013): Vol 25 Issue 2

Abstract

Organotin(IV) carboxylate complexes derivatives of 3-methyl-4-nitrobenzoic acid (3-CH3-4-NO2-C6H3COOH) and 4-methyl-3-nitrobenzoic acid (4-CH3-3-NO2-C6H3COOH) have been successfully synthesized. Two dibutyltin(IV) complexes with the general formulae {[X-CH3-Y-NO2-C6H3COO(C4H9)2Sn]2O}2 (X = meta, Y = para 1; X = para, Y = meta 3) and another two triphenyltin(IV) complexes with the general formulae X-CH3-Y-NO2-C6H3COO(C6H5)3Sn·CH3OH (X = meta, Y = para 2; X = para, Y = meta 4) were successfully synthesized. The acids and complexes 1-4 obtained were characterized quantitatively and qualitatively. Results of the infrared and NMR spectroscopy on the acids and complexes showed that the coordination took place via oxygen atoms from the carboxylate anions. Based on the spectroscopy studies indicated that one methanol molecule also take part in the coordination to tin(IV) atoms moiety in complexes 2 and 4 resulting the tin(IV) atoms exhibited five coordination. From the preliminary in vitro antibacterial screening activity, triphenyltin(IV) complexes (2 and 4) showed better activity compared to diorganotin(IV) complexes (1 and 3).

Keywords

Organotin(IV) complexes Synthesis Characterization In vitro antibacterial activity
Win, Y.-F., Choong, C.-S., Ha, S.-T., Teoh, S.-G., & Eltaher Eltayeb, N. (2012). Synthesis and Characterization of Organotin(IV) Complexes Derivatives of Methyl- and Nitro- Substituted Monocarboxylic Acid: Preliminary in vitro Antibacterial Screening Activity. Asian Journal of Chemistry, 25(2), 972–976. https://doi.org/10.14233/ajchem.2013.13292
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