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Vol. 25 No. 2 (2013): Vol 25 Issue 2

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Differential Effect of Metal Ions on Antibacterial Activity of Chitosan Against Burkholderia cenocepacia

https://doi.org/10.14233/ajchem.2013.13052
B. Li
State Key Laboratory of Rice Biology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Ministry of Agriculture, Institute of Biotechnology, Zhejiang University, Hangzhou 310029, P.R. China
Y. Fang
State Key Laboratory of Rice Biology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Ministry of Agriculture, Institute of Biotechnology, Zhejiang University, Hangzhou 310029, P.R. China
C.L. Shan
State Key Laboratory of Rice Biology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Ministry of Agriculture, Institute of Biotechnology, Zhejiang University, Hangzhou 310029, P.R. China
M. Ibrahim
State Key Laboratory of Rice Biology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Ministry of Agriculture, Institute of Biotechnology, Zhejiang University, Hangzhou 310029, P.R. China
G.L. Xie
State Key Laboratory of Rice Biology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Ministry of Agriculture, Institute of Biotechnology, Zhejiang University, Hangzhou 310029, P.R. China
Y.L. Wang
State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, P.R. China
G.C. Sun
State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, P.R. China

Corresponding Author(s) : B. Li

libin0571@zju.edu.cn

Asian Journal of Chemistry, Vol. 25 No. 2 (2013): Vol 25 Issue 2

Abstract

In this study, the antibacterial activity of chitosan and chitosan metal salts against Burkholderia cenocepacia isolated from cystic fibrosis patients was investigated. Results showed that chitosan solution at 0.01, 0.05 and 0.10 mg/mL markedly inhibited the growth of B. cenocepacia Y10 although the antibacterial activity decreased with the increase of chitosan concentration. However, the antibacterial activity of chitosan solution against B. cenocepacia Y20 increased with the increase of chitosan concentration up to 0.05 mg/mL. In addition, the antibacterial activity of chitosan solution against B. cenocepacia strains was decreased by NaCl, CaCl2 and MgCl2. However, both ZnCl2 and FeCl3 significantly enhanced the antibacterial activity of chitosan solution regardless of the tested bacterial strains. Overall, the results indicated that chitosan-Zn or chitosan-Fe complex may be a promising candidate for novel antimicrobial agents in pharmaceutical industry.

Keywords

Antibacterial activity Burkholderia cenocepacia Chitosan Concentration Metal ions
Li, B., Fang, Y., Shan, C., Ibrahim, M., Xie, G., Wang, Y., & Sun, G. (2012). Differential Effect of Metal Ions on Antibacterial Activity of Chitosan Against Burkholderia cenocepacia. Asian Journal of Chemistry, 25(2), 891–894. https://doi.org/10.14233/ajchem.2013.13052
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