Issue

Vol. 25 No. 2 (2013): Vol 25 Issue 2

Copyright (c) 2013 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Nephroprotective Effects and Its Mechanism of an Herbal Prescription on Diabetic Nephropathy Rats

https://doi.org/10.14233/ajchem.2013.12897
H.Z. Cai
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, P.R. China ; Department of Nutrition and Food Hygiene, School of Public Health, NingXia Medicine University, NingXia, P.R. China
S.K. Wang
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, P.R. China
J.L. Sheng
Department of Foodborne Disease Surveillance and Environmental Control, Center for Disease Control and Prevention, ChangZhou, P.R. China
P.L. Huang
Department of Pathophysiology, School of Medicine, Southeast University, Nanjing, P.R. China
G.J. Sun
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, P.R. China

Corresponding Author(s) : G.J. Sun

gjsun@seu.edu.cn

Asian Journal of Chemistry, Vol. 25 No. 2 (2013): Vol 25 Issue 2

Abstract

The work aims at investigating protective effects and mechanism of an herbal prescription (162.5 mg/kg-650 mg/kg bw/d) composed of tea and lycium bararum polysaccharides and Eucommia ulmoides on diabetic nephropathy. Following parameters were measured: (1) body weights, 24 h's urine volume, urine protein, serum glucose and insulin levels, blood urea nitrogen, serum creatinine, advanced glycosylation end products (AGEs); (2) kidney weight, aldose reductase and protein kinase C in kidney tissue; (3) histopathology of kidney. Body weight and albuminuria of diabetic nephropathy rats were improved and blood glucose, blood urea nitrogen and serum creatinine were decreased. Excretion and sensitivity to insulin was activated. Moreover, the prescription evoked normalisation of diabetes-stimulated kidney NADPH oxidase and reduced levers of advanced glycosylation end products and percentages of cell membrane protein kinase C activity accounted for gross activity. It also restrained thickening of glomerular mesangial area and basement membrane and degeneration of tubular. The prescription seems to be benefit for preventing development of diabetic nephropathy.

Keywords

NIDDM Diabetic nephropathy Tea polysaccharides Lycium bararum polysaccharides Eucommia ulmoides
Cai, H., Wang, S., Sheng, J., Huang, P., & Sun, G. (2012). Nephroprotective Effects and Its Mechanism of an Herbal Prescription on Diabetic Nephropathy Rats. Asian Journal of Chemistry, 25(2), 775–779. https://doi.org/10.14233/ajchem.2013.12897
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. P. Balakumar, M.K. Arora, S.S. Ganti, J. Reddy and M. Singh, Pharmacol. Res., 60, 24 (2009).
  2. H.R. Liu, X.Y. Tang, D.Z. Dai and Y. Dai, J. Ethnopharmacol., 118, 466 (2008).
  3. L. Lin, Q. Ni, and Q.J. Gao, Chin. J. Integr. Med., 8, 19 (2002).
  4. R. Zhao, Q.W. Li, J. Li and T. Zhang, Can. J. Physiol. Pharmacol., 87, 711 (2009).
  5. F. Marotta, M. Harada, E.D. Dallah, H. Yadav, U. Solimene, S. Di Lembo, E. Minelli, S. Jain and D.H. Chui, J. Biol. Regul. Homeost. Agents, 24, 41 (2010).
  6. H. Chen, Z. Qu, L. Fu, P. Dong and X. Zhang, J. Food Sci., 74, C469 (2009).
  7. X. Zhou, D. Wang, P. Sun, P. Bucheli, L. Li, Y. Hou and J. Wang, J. Agric. Food Chem., 55, 5523 (2007).
  8. W.W. Dongfeng, W.W. Chenghong, L.L. Jun and Z.Z. Guiwen, J. Agric. Food Chem., 49, 507 (2001).
  9. R. Zhao, Q. Li and B. Xiao, Yakugaku Zasshi, 125, 981 (2005).
  10. J. Huang, G. Sun, Ju, H. Li and L. Yang, Gang. Food Res. Develop., 27, 77 (2006).
  11. X. Guo, Z. Hua, H. Liu and H. Li, Chin. J. Diabets, 10, 290 (2002).
  12. S. Sun, Y. Wang, Q. Li, Y. Tian, M. Liu and Y. Yu, Chin. Med. J. (Eng), 119, 814 (2006).
  13. K. Wrobel, M.E. Garay-Sevilla, L.E. Nava and J.M. Malacara, Clin. Chem., 43, 1563 (1997).
  14. M.L. Thorp, Am. Fam. Physician, 72, 96 (2005).
  15. D. Porte and M.W. Schwartz Jr., Science, 272, 699 (1996).
  16. E.A. Friedman, Nephrol Dial Transplant, 14S, 1 (1999).
  17. S. Dronavalli, I. Duka and G.L. Bakris, Nat. Clin. Pract. Endocrinol. Metab., 4, 444 (2008).
  18. A.K. Singh, W. Mo, G. Dunea and J.A. Arruda, J. Am. Soc. Nephrol., 9, 802 (1998).
  19. P. Balakumar, M.K. Arora, J. Reddy and M.B. Anand-Srivastava, J. Cardiovasc. Pharmacol., 54, 129 (2009).
  20. M.E. Cooper, Lancet, 352, 213 (1998).
  21. S. Yamagishi, K. Fukami, S. Ueda and S. Okuda, Curr. Drug Targets, 8, 952 (2007).
  22. K. Sharma and F.N. Ziyadeh, Diabetes, 44, 1139 (1995).
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0