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Vol. 25 No. 2 (2013): Vol 25 Issue 2

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Interaction of DNA with Cu(II) and Co(II) Complexes with Fused Aromatic N-Containing Ligand

https://doi.org/10.14233/ajchem.2013.12888
M. Lashanizadegan
Department of Chemistry, Faculty of Science, Alzahra University, Vanak, Tehran, Iran
S. Shekarsaraii
Department of Chemistry, Faculty of Science, Alzahra University, Vanak, Tehran, Iran

Corresponding Author(s) : M. Lashanizadegan

m_lashani@alzahra.ac.ir

Asian Journal of Chemistry, Vol. 25 No. 2 (2013): Vol 25 Issue 2

Abstract

Three new complexes of fused aromatic N-containing ligands such as [CuL]Cl2 (1) and [CoL]Br2 (2) (L = 3,10-bis(2-(p-nitrophenyl))-1,3,5,8,10,13-hexaazacyclotetradecane) and [CuL1]Cl2 (3) [L1 = 3,10-bi-phenyl-1,3,5,8,10,13-hexaazacyclotetradecane) have been synthesized and characterized by UV-VIS and IR spectra. The interactions of DNA with [CuL]Cl2, [CoL]Br2 and [CuL1]Cl2 complexes in 1 mM Tris-HCl aqueous neutral complex-DNA molar ratio have been carried out by UV absorption spectrometry and fluorescence spectroscopy. The results support for an intercalative reaction of three complexes with DNA, showing [CuL1]Cl2 has an affinity of ca. 10 times higher than [CuL]Cl2 and [CuL]Cl2 ten times higher than [CoL]Br2.

Keywords

Transition metal DNA intercalation Fluorescence Copper Macrocyclic
Lashanizadegan, M., & Shekarsaraii, S. (2012). Interaction of DNA with Cu(II) and Co(II) Complexes with Fused Aromatic N-Containing Ligand. Asian Journal of Chemistry, 25(2), 767–770. https://doi.org/10.14233/ajchem.2013.12888
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