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Synthesis of Novel Quinazolinone Derivatives with Methyl (E)-2-(3-methoxy)acrylate Moiety
Corresponding Author(s) : Yu-liang Wang
Asian Journal of Chemistry,
Vol. 25 No. 2 (2013): Vol 25 Issue 2
Abstract
A new series of quinazolinone derivatives with methyl (E)-2-(3-methoxy)acrylate moiety have been designed and synthesized. All target compounds had been identified by 1H NMR spectrum, IR spectrum and HR-MS (high resolution mass spectrum). Three target compounds (10a, 10e, 10h) were chosen to preliminarily test the antibacterial activities, the results showed that all three target compounds exhibited antibacterial activities against three bacterial strains (Proteobacteria, Salmonella, Colibacillus).
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References
J.M. Huang, Chem. J. Chin. Univ., 8, 1216 (2000).
P.R. Russell, Pesticides, 27, 33 (1988).
S. Jantova, S. Stankovsk and K. Spirakova, Biologica Bratislava, 59, 741 (2004).
Y. Zhou, D. Murphy, Z. Sun and V. Greogr, Tetrahedron Lett., 45, 8049 (2004).
P. Panneerselvam, B.A. Rather, D.R.S. Reddy and N.R. Kumar, Eur. J. Med. Chem., 44, 2328 (2009).
P.M. Chandrika, T. Yakaiah,A.R.R. Rao, B. Narsaiah, N. Chakra Reddy, V. Sridhar and J.V. Rao, Eur. J. Med. Chem., 43, 846 (2008).
W.P. Emanuel, U.S. Patent 3320124 (1967).
C.C. Norton and D.R. Wise, The Veter. Rec., 109, 554 (1981).
J.H. You, C.W. Ye, Y.B. Weng, X.H. Mo and Y.L. Wang, Arkivoc, 1 (2008).
Y.Y. Zhang and G.M. Chen, Lett. Drug Design Discov., 7, 471 (2010).
C.W. Ye and J.H. You, Pesticide Biochem. Physiol., 97, 194 (2010).
Y.-P. Yao and F.-Y. Dai, J. Chem. Res., 4 (2011).
W.A. Battaglin, M.W. Sandstrom, K.M. Kuivila, D.W. Kolpin and M.T. Meyer, Water Air Soil Pollut., 218, 307 (2011).
J. Dong, D.-H. Liao, J.-S. Lou and H.-J. Pi, Fine Chem. Intermed., Vol. 37, No. 2.