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Isolation of an Antifungal Compound from Anaphalis sinica Hance
Corresponding Author(s) : Ke Tao
Asian Journal of Chemistry,
Vol. 25 No. 1 (2013): Vol 25 Issue 1
Abstract
The present investigation was in order to isolate antifungal constituents from Anaphalis sinica Hance, using activity against several phytopathogenic fungi as a lead. Bioactivity guided fractionation of the petroleum ether extract has led to the isolation of a tremetone derivative (compound 1), whose structure had been elucidated as 4,6-dihydroxy-14,14-dimethyltremeton based on extensive 1D and 2D NMR and HR-ESI-MS spectral data. Compound 1 had exhibited excellent antifungal activity against Valsa mali, Elsinoe ampelina and Gibberella saubinetii and the values of their EC50 reached 2.27, 7.18 and 12.30 μg/mL respectively, that was comparable to the commercial fungicide carbendazim, whose EC50 values were 1.60, 33.54 and 6.60 μg/mL respectively.
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- Delectis Florae Reipublicae Popularis Sinicae Agendae Academiae Sinicae Edita, Flora Reipublicae Popularis Sinicae, Beijing, Science Press, Vol. 75 (1979).
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- A. Ni, Changchun and S. Zhou, Mod. Agrochem., 3, 10 (2004).
- T. Hou, Y. Teng, Q. Sun and Z. Yu, Fitoterapia, 80, 237 (2009).
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References
Delectis Florae Reipublicae Popularis Sinicae Agendae Academiae Sinicae Edita, Flora Reipublicae Popularis Sinicae, Beijing, Science Press, Vol. 75 (1979).
College JNM, The Encyclopedia of Traditional Chinese Medicine, (Shanghai, Shanghai Science and Technology Press, Vol. 1821 (1985).
Y.Q. Wu, S. Li, Y. Li and Y. Li, Chin. Chem. Lett., 14, 66 (2003).
Z.Y. Ren, Y. Zhang and Y.P. Shi, Talanta, 78, 959 (2009).
Z.Y. Ren, Q.X. Wu and Y.P. Shi, Chem. Nat. Compd., 45, 728 (2009).
Y. Hua and H.Q. Wang, J. Chin. Chem. Soc.-Taip., 51, 409 (2004).
A.X. Wang, F.L. Yan and Z.H. Jia, Chin. Chem. Lett., 15, 1185 (2004).
Z.Y. Ren, H.Y. Qi and Y.P. Shi, Planta Med., 74, 859 (2008).
A.A. Ahmed, T.A. Hussein, A.A. Mahmoud, M.A. Farag, P.W. Pare, M. Wojcinska, J. Karchesy and T.J. Mabry, Phytochemistry, 65, 2539 (2004).
R.K. Joshi, C. Pande, M.H.K. Mujawar and S.D. Kholkute, Nat. Prod. Commun., 4, 993 (2009).
A. Ni, Changchun and S. Zhou, Mod. Agrochem., 3, 10 (2004).
T. Hou, Y. Teng, Q. Sun and Z. Yu, Fitoterapia, 80, 237 (2009).
W. Huang and G.F. Yang, Bioorg. Med. Chem., 14, 8280 (2006).
X.H. Li, D.C. Wu, Z.Q. Qi, X.W. Li, Z.M. Gu, S.H. Wei, Y. Zhang, Y.Z. Wang and M.S. Ji, J. Agric. Food Chem., 58, 11384 (2010).
Z.J. Song and Y.S. Xia, Asian J. Ecotoxicol., 5, 420 (2010).