Diaryl Pyrazole-4-carbaldehyde Benzoylhydrazones Metal Complexes: Synthesis and Their Antibacterial and Antioxidant Screening

Muhammad Nasrullah; Misbahul Ain Khan; Muhammad Naeem Khan; Mark G. Humphrey; Faizul Hassan Nasim; Faryal Chaudhry; Moeena Ghazal Abidi; Umar Farooq; Munawar Ali Munawar

doi:10.14233/ajchem.2013.13131

Issue

Vol. 25 No. 1 (2013): Vol 25 Issue 1

Issue Published : August 6, 2012

This work is licensed under a Creative Commons Attribution 4.0 International License.

Diaryl Pyrazole-4-carbaldehyde Benzoylhydrazones Metal Complexes: Synthesis and Their Antibacterial and Antioxidant Screening

https://doi.org/10.14233/ajchem.2013.13131

Muhammad Nasrullah

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Misbahul Ain Khan

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Muhammad Naeem Khan

Applied Chemistry Research Centre, PCSIR Laboratories Complex, Lahore, Pakistan

Mark G. Humphrey

Research School of Chemistry, Australian National University, Canberra, Australia

Faizul Hassan Nasim

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Faryal Chaudhry

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Moeena Ghazal Abidi

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Umar Farooq

Institute of Chemistry, University of the Punjab, Quaid-i-Azam Campus, Lahore, Pakistan

Munawar Ali Munawar

Institute of Chemistry, University of the Punjab, Quaid-i-Azam Campus, Lahore, Pakistan

Corresponding Author(s) : Muhammad Naeem Khan

changwani_1@yahoo.com

Asian Journal of Chemistry, Vol. 25 No. 1 (2013): Vol 25 Issue 1
Article Published : August 16, 2012

Abstract

Various heterocyclic ligands [1,3-diarylpyrazole-4-carbaldehyde benzoyl-hydrazones] and their metal complexes with Cu²⁺, Ni²⁺, Co²⁺, Pb²⁺, Zn²⁺ and Fe²⁺ have been synthesized, characterized and screened for their antibacterial and antioxidant activities. The synthesized compounds were characterized through elemental analysis and spectroscopic techniques (FTIR, ¹H NMR and Mass).

Keywords

Aryl pyrazoles Vilsmeier-Haack reaction Transition metal complexes Antioxidant and antibacterial studies

Nasrullah, M., Ain Khan, M., Naeem Khan, M., G. Humphrey, M., Hassan Nasim, F., Chaudhry, F., … Ali Munawar, M. (2012). Diaryl Pyrazole-4-carbaldehyde Benzoylhydrazones Metal Complexes: Synthesis and Their Antibacterial and Antioxidant Screening. Asian Journal of Chemistry, 25(1), 419–423. https://doi.org/10.14233/ajchem.2013.13131

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References

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D.X. West, S.B. Padhye and P.B. Sonawane, Struct. Bond., 76, 1 (1991).
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References

D.L. Klayman, J.F. Bartosevich, T.S. Griffin, C.J. Mason and J.P. Scovill, J. Med. Chem., 22, 855 (1979).

D.X. West, S.B. Padhye and P.B. Sonawane, Struct. Bond., 76, 1 (1991).

A.E. Liberta and D.X. West, Biometals, 5, 121 (1992).

F.A. French, E.J. Blanz, J.R. Do Amaral and D.A. French, J. Med. Chem., 13, 1117 (1970).

H. Beraldo and D. Gambino, Mini Rev. Chem., 4, 31 (2004).

S. Rollas and S.G. Kucukguzel, Molecules, 12, 1910 (2007).

E.W. Ainscough, A.M. Brodie, W.A. Denny, G.J. Finlay, S.A. Gothe and J.D. Ranford, J. Inorg. Biochem., 77, 125 (1999).

D. Van Reyk, S. Sarel and N. Hunt,Biochem. Pharmacol., 60, 581 (2000).

I. Ahmad, M.A. Khan and M. Ather, Pak. J. Sci. Ind. Res., 43, 38 (2000).

I. Ahmad, M.A. Khan and M. Ather, J. Pure Appl. Sci., 17, 67 (1998).

I. Ahmad, M. A. Khan, M. Ather, Pak. J. Sci. Ind. Res., 44, 268 (2001)

O. Prakash, K. Pannu and A. Kumar, Molecules, 11, 43 (2006).

V.M. Leovac, S.B. Novakovic, G.A. Bogdanovic, M.D. Joksovic, K.M. Szecsenyi and V.M. Cesljevic, Polyhedron, 26, 3783 (2007).

D.L. Pavia, G.M. Lampman and G.S. Kriz, Introduction to Spectroscopy, Thomson Learning Inc. USA (2001).

R.T. Conley, Infrared Spectroscopy, Allyn and Bacom Inc. Boston, USA (1972).

M. Kaspady, V.K. Narayanaswamy, M. Raju and G.K. Rao, Lett. Drug Design Discov., 6, 21 (2009).

A.K. Patel, R.J. Patel, K.H. Patel and R.M. Patel, J. Chil. Chem. Soc., 54, 228 (2009).

D.C. Garret, Quantitative Analysis of Drugs, Chapman and Hall, Japan, Vol. 3, p. 456 (1964)

Issue

Vol. 25 No. 1 (2013): Vol 25 Issue 1

Diaryl Pyrazole-4-carbaldehyde Benzoylhydrazones Metal Complexes: Synthesis and Their Antibacterial and Antioxidant Screening

Corresponding Author(s) : Muhammad Naeem Khan

Abstract

Keywords

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