Synthesis, Spectral and Biological Studies of Novel Schiff Base Metal Complexes Derived from Cephalexin and Sugars

Narjis Naz; Zubi Sadiq; Muhammad Zafar Iqbal

doi:10.14233/ajchem.2013.13005

Issue

Vol. 25 No. 1 (2013): Vol 25 Issue 1

Issue Published : August 6, 2012

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Spectral and Biological Studies of Novel Schiff Base Metal Complexes Derived from Cephalexin and Sugars

https://doi.org/10.14233/ajchem.2013.13005

Narjis Naz

Department of Chemistry, Lahore College for Women University, Lahore-54000, Pakistan

Zubi Sadiq

Department of Chemistry, Lahore College for Women University, Lahore-54000, Pakistan

Muhammad Zafar Iqbal

Department of Chemistry, Lahore College for Women University, Lahore-54000, Pakistan

Corresponding Author(s) : Narjis Naz

narjis107@gmail.com

Asian Journal of Chemistry, Vol. 25 No. 1 (2013): Vol 25 Issue 1
Article Published : August 16, 2012

Abstract

Fe(II), Co(II) and Ni(II) metal complexes of novel Schiff bases derived from cephalexin and sugars (D-glucose, D-xylose) were synthesized and characterized by physio-chemical (elemental analysis, magnetic susceptibility and electrolytic conductance) and spectral techniques. It has been found that Schiff bases behave as bidentate ligands forming complexes with 1:2 (metal:ligand) stoichiometry. Thermal behaviour of complexes has been investigated using thermogravimetric techniques. The biological activities of complexes have been evaluated against two gram negative (Escherichia coli and Pseudomonas aeruginosa) and two gram positive (Bacillus subtilis and Staphylococcus aureus) bacteria by Agar diffusion disc method. It has been found that the complexes have higher activity as compared to the pure cephalexin against the bacteria.

Keywords

Schiff base complexes Cephalexin Sugars

Naz, N., Sadiq, Z., & Zafar Iqbal, M. (2012). Synthesis, Spectral and Biological Studies of Novel Schiff Base Metal Complexes Derived from Cephalexin and Sugars. Asian Journal of Chemistry, 25(1), 297–300. https://doi.org/10.14233/ajchem.2013.13005

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References

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J.G. Lara, M. Masalha and S.J. Foster, Drug Discovery Today, 10, 643 (2005).
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R. Ramesh and M. Sivagamasundari, Synth. React. Inorg. Met.-Org. Chem., 33, 809 (2003).
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W. Radecka-Paryzek, V. Patroniak and J. Lisowski, Coord. Chem. Rev., 249, 2156 (2005).
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Z.H. Chohan and S.K.A. Sheazi, Synth. React. Inorg. Met.-Org. Chem., 29, 105 (1999).
A.K. Halve, D. Bhadauria, B. Bhaskar, R. Dubey and S. Vasudha, Indian J. Pharm. Sci., 69, 680 (2007).
V.K. Tandon, D.B. Yadav, R.V. Singh, M. Vaish, A.K. Chaturvedi and P.K. Shukla, Bioorg. Med. Chem., 15, 3463 (2007).
A.K. Sadana, Y. Miraza, K.R. Aneja and O. Prakash, Eur. J. Med. Chem., 38, 533 (2003).
D.E. Metzler, J. Am. Chem. Soc., 91, 627 (1968).
M.S. Iqbal, S.J. Khurshid and M.Z. Iqbal,Can. J. Chem., 71, 629 (1993).
S.M.E. Khalil, S.L. Stefan and K.A. Bashir, Synth. React. Inorg. Met.- Org. Chem., 29, 1685 (1999).
M. Sekerci and E. Tas, Heteroatom Chem., 11, 254 (2000).
B. Bosnich, J. Am. Chem. Soc., 90, 627 (1968).
R.S. Downing and F.L. Urbach, J. Am. Chem. Soc., 91, 5977 (1969).
M. Sonmez and M. Sekerci, Polish J. Chem., 76, 907 (2002).
F.A. Cotton and G. Wilkinson, Advance Inorganic Chemistry, Academic Press, New York, edn. 4, p. 790 (1980).
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R.L. Duta and A. Syamal, Elements of Magnetochemistry, edn. 2 (1992).
R. Di Stefano, M. Scopelliti, C. Pellerito, G. Casella, T. Fiore, G.C. Stocco, R. Vitturi, M. Colomba, L. Ronconi, I.D. Sciacca and L. Pellerito, J. Inorg. Biochem. 98, 534 (2004).
P.K. Bhattacharrya and W.M. Cort,Analytical Profiles of Drug Substances, p. 28 (1978).
E. Ivashikiv, Analytical Profiles of Drug Substances, p. 5 (1973).
K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, New York, NY: John Wiley Interscience, p. 59 (1997).
N. Raman, S. Ravichandran and A. Kulandaisamy, Asian J. Chem., 14, 1261 (2002).
R.K. Agarwal, D. Sharma, L. Singh and H. Agarwal, Bioinorg. Chem. Appl., article 29234 (2006).
Z.H. Chohan, M. Arif, M.A. Akhtar and C.T. Supuran, Bioinorg. Chem. Appl., article 83131 (2006).
G.B. Deacon, F. Huber and R.J. Phillips, Inorg. Chim. Acta, 41, 104 (1985).
X. Tai, X. Yin, Q. Chen and M. Tan, Molecules, 8, 439 (2003).
N. Raman and S. Ravichandran, Polish J. Chem., 78 (2004).
E. Canpolat and M. Kaya, Russian J. Chem., 31, 415 (2005).
Z.H. Chohan, C.T. Supuran and A. Scozzafava, J. Enzyme Inhib. Med. Chem., 19, 79 (2004).

References

K. Singh, M.S. Barwa and P. Tyagi, Eur. J. Med. Chem., 42, 394 (2007).

J.G. Lara, M. Masalha and S.J. Foster, Drug Discovery Today, 10, 643 (2005).

S. Tehranchian, T. Akbarzadeh, M.R. Fazeli, H. Jamalifar and A. Shafiee, Bioorg. Med. Lett., 5, 1023 (2005).

N. Gumrukcouglu, M. Serdar, E. Celik, A. Sevim and N. Demirbas, Turk. J. Chem., 31, 335 (2007).

M.S. Iqbal, I.H. Bukhari and M. Arif, Appl. Organomet. Chem., 19, 864 (2005).

G.B. Bagihalli, P.G. Avaji, S.A. Patil and P.S. Badami, Eur. J. Med. Chem., 43, 2639 (2008).

N. Raman, J.D. Raja and A. Sakthivel, J. Chem. Sci., 119, 303 (2007).

M.S. Iqbal,A.R. Ahmad, M. Sabir and S.M. Asad, J. Pharm. Pharmacol., 51, 371 (1999).

Z.H. Chohan and M.F. Jaffery, Metal Based Drugs, 7, 265 (2000).

R. Di Stefano, M. Scopelliti, C. Pellerito, T. Fiore, R. Vitturi, M.S. Colomba, P. Gianguzza, G.C. Stoccoa, M. Consiglioa and L. Pelleritoa, J. Inorg. Biochem., 89, 279 (2002).

R. Ramesh and M. Sivagamasundari, Synth. React. Inorg. Met.-Org. Chem., 33, 809 (2003).

P. Singh, R.L. Goel and B.P. Singh, J. Indian Chem. Soc., 52, 958 (1975).

A.M. Mahindra, J.M. Fisher and Rabinovitz, Nature (London), 64, 303 (1983).

M. Sonmez, Turk. J. Chem., 25, 181 (2001).

K.S. Abou-Melha and H. Faruk, J. Iran. Chem. Soc., 5, 122 (2008).

W. Radecka-Paryzek, V. Patroniak and J. Lisowski, Coord. Chem. Rev., 249, 2156 (2005).

N. Raman, A. Kulandaisamy and K. Jeyasubramanian, Transition Met. Chem., 26, 131 (2001).

M. Sonmez, Polish J. Chem., 77, 397 (2003).

C. Spinu and A. Kriza, Acta Chim. Slov., 47, 179 (2000).

S. Baluja, A. Aolanki and N. Kachhadia, J. Iran. Chem. Soc., 3, 312 (2006).

N. Naz and M.Z. Iqbal, J. Chem. Soc. Pak., 31, 440 (2009).

N. Naz and M.Z. Iqbal, Sci. Int., 23, 27 (2011).

Z.H. Chohan and S.K.A. Sheazi, Synth. React. Inorg. Met.-Org. Chem., 29, 105 (1999).

A.K. Halve, D. Bhadauria, B. Bhaskar, R. Dubey and S. Vasudha, Indian J. Pharm. Sci., 69, 680 (2007).

V.K. Tandon, D.B. Yadav, R.V. Singh, M. Vaish, A.K. Chaturvedi and P.K. Shukla, Bioorg. Med. Chem., 15, 3463 (2007).

A.K. Sadana, Y. Miraza, K.R. Aneja and O. Prakash, Eur. J. Med. Chem., 38, 533 (2003).

D.E. Metzler, J. Am. Chem. Soc., 91, 627 (1968).

M.S. Iqbal, S.J. Khurshid and M.Z. Iqbal,Can. J. Chem., 71, 629 (1993).

S.M.E. Khalil, S.L. Stefan and K.A. Bashir, Synth. React. Inorg. Met.- Org. Chem., 29, 1685 (1999).

M. Sekerci and E. Tas, Heteroatom Chem., 11, 254 (2000).

B. Bosnich, J. Am. Chem. Soc., 90, 627 (1968).

R.S. Downing and F.L. Urbach, J. Am. Chem. Soc., 91, 5977 (1969).

M. Sonmez and M. Sekerci, Polish J. Chem., 76, 907 (2002).

F.A. Cotton and G. Wilkinson, Advance Inorganic Chemistry, Academic Press, New York, edn. 4, p. 790 (1980).

N.N. Green and A. Earnshaw, Chemistry of the Elements, Pergamon Press, Oxford, U.K., p. 1315 (1984).

R.L. Duta and A. Syamal, Elements of Magnetochemistry, edn. 2 (1992).

R. Di Stefano, M. Scopelliti, C. Pellerito, G. Casella, T. Fiore, G.C. Stocco, R. Vitturi, M. Colomba, L. Ronconi, I.D. Sciacca and L. Pellerito, J. Inorg. Biochem. 98, 534 (2004).

P.K. Bhattacharrya and W.M. Cort,Analytical Profiles of Drug Substances, p. 28 (1978).

E. Ivashikiv, Analytical Profiles of Drug Substances, p. 5 (1973).

K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, New York, NY: John Wiley Interscience, p. 59 (1997).

N. Raman, S. Ravichandran and A. Kulandaisamy, Asian J. Chem., 14, 1261 (2002).

R.K. Agarwal, D. Sharma, L. Singh and H. Agarwal, Bioinorg. Chem. Appl., article 29234 (2006).

Z.H. Chohan, M. Arif, M.A. Akhtar and C.T. Supuran, Bioinorg. Chem. Appl., article 83131 (2006).

G.B. Deacon, F. Huber and R.J. Phillips, Inorg. Chim. Acta, 41, 104 (1985).

X. Tai, X. Yin, Q. Chen and M. Tan, Molecules, 8, 439 (2003).

N. Raman and S. Ravichandran, Polish J. Chem., 78 (2004).

E. Canpolat and M. Kaya, Russian J. Chem., 31, 415 (2005).

Z.H. Chohan, C.T. Supuran and A. Scozzafava, J. Enzyme Inhib. Med. Chem., 19, 79 (2004).

Issue

Vol. 25 No. 1 (2013): Vol 25 Issue 1

Synthesis, Spectral and Biological Studies of Novel Schiff Base Metal Complexes Derived from Cephalexin and Sugars

Corresponding Author(s) : Narjis Naz

Abstract

Keywords

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