Synthesis, Characterization and Antimicrobial Studies of Novel Binuclear Transition Metal Complexes of Schiff Base Derived from 1-Amino-5-methyl-2,6-pyrimidine-dione and 2,3-Butanedione

Netra Pal Singh; Abhay Nanda Srivastava

doi:10.14233/ajchem.2013.13484

Issue

Vol. 25 No. 1 (2013): Vol 25 Issue 1

Issue Published : August 6, 2012

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization and Antimicrobial Studies of Novel Binuclear Transition Metal Complexes of Schiff Base Derived from 1-Amino-5-methyl-2,6-pyrimidine-dione and 2,3-Butanedione

https://doi.org/10.14233/ajchem.2013.13484

Netra Pal Singh

Department of Chemistry, Meerut College, Meerut-250 001, India

Abhay Nanda Srivastava

Department of Chemistry, Meerut College, Meerut-250 001, India

Corresponding Author(s) : Netra Pal Singh

npsmcm.in@gmail.com

Asian Journal of Chemistry, Vol. 25 No. 1 (2013): Vol 25 Issue 1
Article Published : August 16, 2012

Abstract

A series of binuclear transition metal complexes of the type [M₂(L)₂X₄)]·nH₂O (where, M = Cu(II), Ni(II), Co(II) or Zn(II), X= Cl^–/CH₃COO^– and L = ligand) of a Schiff base ligand derived from 1-amino-5-methyl-2,6-pyrimidine-dione and 2,3-butanedione have been synthesized and characterized by elemental analysis, molar conductance measurements, magnetic moment measurements, IR, UV-visible, ¹H NMR, EPR and mass spectral studies. Electronic spectral data and magnetic moment values indicate octahedral geometry for all the metal complexes. In vitro antimicrobial activity of ligand and its metal complexes were also studied against bacteria (Bacillus subtilis and Escherichia coli) and fungi (Aspergillus niger and Aspergillus flavus) which show antimicrobial activity of ligand and binuclear metal complexes.

Keywords

Octahedral metal complexes Amino-pyrimidine Antimicrobial activity Schiff base

Pal Singh, N., & Nanda Srivastava, A. (2012). Synthesis, Characterization and Antimicrobial Studies of Novel Binuclear Transition Metal Complexes of Schiff Base Derived from 1-Amino-5-methyl-2,6-pyrimidine-dione and 2,3-Butanedione. Asian Journal of Chemistry, 25(1), 533–537. https://doi.org/10.14233/ajchem.2013.13484

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References

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References

J.A.R. Navarro and B. Lippert, Coord. Chem. Rev., 222, 219 (2001).

M. Sonmez, M. Celebi and I. Berber, Eur. J. Med. Chem., 4, 1935 (2010).

S.E.M. Khali, H.S. Saleem, B.A. El-Shetary and M. Shebl, J. Coord. Chem., 55, 883 (2002).

T.F. Mastropietro, D. Armentano, E. Grisolia, C. Zanchini, F. Lloret, M. Julve and G.D. Munno, J. Chem. Soc. Dalton Trans., 514 (2008).

E. Colacio, J.M. Dominguez-Vera, A. Romerosa, R. Kivekas, M. klinga and A. Escuer, Inorg. Chim. Acta, 234, 61 (1995).

M.S. Masoud, E.A. Khalil,A.M. Hindawy, A.E. Ali and E.F. Mohamed, Spectrochim. Acta A, 60, 2807 (2004).

M.D. Revenco, O.V. Palamarciuc, P.N. Bourosh, J. Lipkowski, M. Gdaniec, Y.A. Simonov and R. Clerac, Inorg. Chim. Acta, 368, 157 (2011).

S. Tabassum, G.C. Sharma, F. Arjmand and A. Azam, Nanotechnology, 21, 195102 (2010).

N.P. Singh and A.N. Srivastava, E-J. Chem., 8, 809 (2010).

K. Kohda, I. Kobayashi, K. Itano, S. Asano and Y. Kawazoe, Tetrahedron, 49, 3947 (1993).

C.N. Reilley, R.W. Schmidt and F.A. Sadek, J. Chem. Educ., 36, 619 (1959).

A.I. Vogel,A Text Book of Quantitative Inorganic Analysis, Longmans, London, p. 433 (1961).

A.K. Sadna, Y. Mirza, A. R. Aneja and O. Prakash, Eur. J. Med. Chem., 38, 533 (2003).

W.J. Geary, Coord. Chem. Rev., 7, 81 (1971).

M. Dolze, M. Tumer and M. Digrak, Transition Met. Chem., 29, 516 (2004).

M.S. Masoud, E.A. Khalil, A.M. Hindway, A.E. Ali and E.F. Mohmed, Spectrochim. Acta A, 60, 2807 (2004).

A. Alagha, L. Parthasrathi, D. Gaynor, H.M. Bunz, Z.A. Starikova, E. Farkas, E.C.O. Brien, M.J. Gil and K.B. Nolan, Inorg. Chim. Acta, 368, 58 (2011).

K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, Wiley, New York (1986).

R.C. Maurya, J. Chourasia and P. Sharma, Indian J. Chem., 47A, 517 (2008).

L.J. Bellamy, The Infrared Spectra of Complex Molecules, Chapmann and Hall, London (1978).

M. Sonmez and M. Sekerci, Polish J. Chem., 76, 907 (2002).

G. Kumar, D. Kumar, S. Devi, R. Johri and C.P. Singh, Eur. J. Med. Chem., 45, 3056 (2010).

R.M. Silverstein, C.M. Bassler and T.C. Morrill, Spectrometric Identification of Organic Compounds, New York: John Wiley, edn. 3 (1974).

G. Ferguson, J.N. Low, M. Quiros-Olozabal, J.M. Salas-Peregrin, F. Hueso-Urena and M.N. Moreno-Carretero, Polyhedron, 15, 3233 (1996).

A.B.P. Lever, Inorganic Electronic Spectroscopy, Elsevier, New York, edn. 2 (1968).

G.G. Mohamed, M.A. Zayed and N.E.A. El-Gamel, Spectrochim. Acta A, 58, 3167 (2002).

A.M. Herrera, R.J. Staples, S.V. Kryotov, A.Y. Nazarenko and E. Vakimova, J. Chem. Soc. Dalton Trans., 846 (2003).

D.R. Lorenz, J.R. Wasson, D.K. Johonson and D.A. Thorpe, J. Inorg. Nucl. Chem., 37, 2297 (1975).

A. Bansal, S. Kumar and R.V. Singh, Synth. React. Inorg. Met. Org. Chem., 31, 1085 (2001).

N. Dharmaraj, P. Viswanathamurthi, K. Natarajan, Transition Met. Chem., 26, 105 (2002)

Issue

Vol. 25 No. 1 (2013): Vol 25 Issue 1

Synthesis, Characterization and Antimicrobial Studies of Novel Binuclear Transition Metal Complexes of Schiff Base Derived from 1-Amino-5-methyl-2,6-pyrimidine-dione and 2,3-Butanedione

Corresponding Author(s) : Netra Pal Singh

Abstract

Keywords

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