Microwave Promoted Synthesis of 2,5-Diaryl-1,3,4-oxadiazoles Using Melamine Formaldehyde Resin Supported Sulfuric Acid

Abstract

A simple and convenient procedure for the synthesis of some 2,5-diaryl-1,3,4-oxadiazoles by reaction of carboxylic acids with (un)substituted benzoic acid hydrazides using melamine formaldehyde resin supported sulfuric acid as dehydration reagent under microwave-accelerated solvent-free condition has been developed. Structures of the corresponding products were elucidated by IR and ¹H NMR spectra and elemental analysis. Results showed that most of the synthesized compounds displayed large Stokes shifts of fluorescence emission.