Synthesis, Structure Elucidation and Study of Antimicrobial Activity of Stannic(IV) Derivatives

Abstract

Six new organotin(IV) compounds with general formulae R₂Sn(OL)₂ and R₃SnOL where R = CH₃, n-C₄H₉, C₆H₅, OL = 4-oxypiperidine were synthesized by the reaction of R₂SnCl₂ and R₃SnCl with stoichiometric amount of 4-hydroxypiperidine in dry ethanol/methanol. These compounds have been characterized by using multinuclear (¹H, ¹³C, ¹¹⁹Sn) NMR and FT-IR spectroscopy. The spectroscopic results revealed that all the diorganotin(IV) compounds possess trigonal-bipyramidal geometry in solution and a tetrahedral environment around the tin atom in non-coordinating solvents, has been proposed for the triorganotin(IV) compounds. All the synthesized compounds were tested in vitro against a number of microorganisms to assess their biocidal activity. The biological activity of these compounds against various strains of bacteria and fungi has revealed promising activity in comparison with Amphotericin B and miconazole as reference drugs. LD₅₀ values of some of the tested compounds showed cytotoxicity.