Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an 710069, Shaanxi Province, P.R. China
Dai-Di Fan
Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an 710069, Shaanxi Province, P.R. China
Jian-Jun Deng
Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an 710069, Shaanxi Province, P.R. China
Jun-Feng Hui
Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an 710069, Shaanxi Province, P.R. China
Xiao-Xuan Ma
Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an 710069, Shaanxi Province, P.R. China
Chen-Hui Zhu
Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an 710069, Shaanxi Province, P.R. China
Wen-Jiao Xue
Shaanxi Provincial Institute of Microbiology, No. 76 Xiying Road, Xi'an 710043, P.R. China
Corresponding Author(s) : Dai-Di Fan
fandaidi@nwu.edu.cn
Asian Journal of Chemistry,
Vol. 25 No. 17 (2013): Vol 25 Issue 17
Injectable in situ forming biodegradable chitosan-human like collagen (CS-HLC) based hydrogels has proved to be a potential candidate as an injectable biomaterial for tissue engineering. With crosslinking agent of carbodiimide, the properties of the novel chitosan-human-like collagen/b-sodium glycerophosphate-carbodiimide hydrogel were also examined. The gelation time, structure, equilibrium swelling and degradation in vitro and in vivo were dependent upon crosslinking and structure of composite hydrogels. The chitosan-human-like collagen/b-sodium glycerophosphate-carbodiimide hydrogel showed a desirable gelling time, swelling ratio, a smooth surface, regular porous networks and biodegradable. Therefore, the chitosan-human-like collagen/b-sodium glycerophosphate-carbodiimide hydrogels are excellent candidates for use in biomedical fields, such as in soft tissue defect filling and drug delivery.
