Synthesis of Podophyllotoxin and its Derivatives via NiCl2/NaBH4 Reduction of Isoxazoline Ring

Meduri Suresh Babu; Kuria Madhavu Lokanatha Rai

doi:10.14233/ajchem.2013.15073

Issue

Vol. 25 No. 17 (2013): Vol 25 Issue 17

Issue Published : 9 November 2013

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis of Podophyllotoxin and its Derivatives via NiCl2/NaBH4 Reduction of Isoxazoline Ring

https://doi.org/10.14233/ajchem.2013.15073

Meduri Suresh Babu

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, India

Kuria Madhavu Lokanatha Rai

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, India

Corresponding Author(s) : Kuria Madhavu Lokanatha Rai

kmlrai@yahoo.com

Asian Journal of Chemistry, Vol. 25 No. 17 (2013): Vol 25 Issue 17
Article Published : 11 November 2013

Abstract

A novel synthesis of podophyllotoxin was carried out in four steps. The key step was reduction of isoxazoline ring followed by diazotization and the resultant alkene was treated with Mn(OAc)₃/CH₃COOK to form podophyllotoxin.

Keywords

Nickel chloride Isoxazoline Podophyllotoxin Maganese acetate

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Suresh Babu, M.; Madhavu Lokanatha Rai, K. Synthesis of Podophyllotoxin and Its Derivatives via NiCl2 NaBH4 Reduction of Isoxazoline Ring. ajc 2013, 25, 9555-9557.