Synthesis of Podophyllotoxin and its Derivatives via NiCl2/NaBH4 Reduction of Isoxazoline Ring
Corresponding Author(s) : Kuria Madhavu Lokanatha Rai
Asian Journal of Chemistry,
Vol. 25 No. 17 (2013): Vol 25 Issue 17
A novel synthesis of podophyllotoxin was carried out in four steps. The key step was reduction of isoxazoline ring followed by diazotization and the resultant alkene was treated with Mn(OAc)3/CH3COOK to form podophyllotoxin.