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Synthesis of Podophyllotoxin and its Derivatives via NiCl2/NaBH4 Reduction of Isoxazoline Ring
Corresponding Author(s) : Kuria Madhavu Lokanatha Rai
kmlrai@yahoo.com
Asian Journal of Chemistry,
Vol. 25 No. 17 (2013): Vol 25 Issue 17
Abstract
A novel synthesis of podophyllotoxin was carried out in four steps. The key step was reduction of isoxazoline ring followed by diazotization and the resultant alkene was treated with Mn(OAc)3/CH3COOK to form podophyllotoxin.
Keywords
Nickel chloride
Isoxazoline
Podophyllotoxin
Maganese acetate
Suresh Babu, M., & Madhavu Lokanatha Rai, K. (2013). Synthesis of Podophyllotoxin and its Derivatives via NiCl2/NaBH4 Reduction of Isoxazoline Ring. Asian Journal of Chemistry, 25(17), 9555–9557. https://doi.org/10.14233/ajchem.2013.15073
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