Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad-500 034, India
Adireddy Dwarampudi
Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad-500 034, India ; Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500 085, India
Venugopalarao Bhatta
Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad-500 034, India
Laxman Kota
Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad-500 034, India
P.K. Dubey
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500 085, India
Corresponding Author(s) : Ramakrishna Nirogi
nvsrk@suven.com
Asian Journal of Chemistry,
Vol. 25 No. 16 (2013): Vol 25 Issue 16
A novel series of rigidized indolyl pyrrolidine derivatives have been designed by constraining the tryptamine nitrogen through a and b carbons. All the synthesized derivatives have shown moderate affinities at 5-HT6R when tested in in vitro binding assay. Synthesis, structure activity relationship (SAR), pharmacokinetic profile and in vivo efficacy of a selected compound is the subject matter of this communication.
Nirogi, R., Dwarampudi, A., Bhatta, V., Kota, L., & Dubey, P. (2013). Synthesis and Structure Activity Relationship of Rigidized Indolyl Pyrrolidine Derivatives as 5-HT6 Receptor Ligands. Asian Journal of Chemistry, 25(16), 9293–9298. https://doi.org/10.14233/ajchem.2013.15443
