Reductive Coupling of Aromatic Aldehydes and Acetophenone Induced by TiCl4-Al/CH2(COOEt)2

Chang-Ying Song; Shu-Xiang Wang; Wen-Hao Chu; Ji-Tai Li; Zheng Zhou; Hong-Yu Li; Zi-Qing Cao

doi:10.14233/ajchem.2013.14890

Issue

Vol. 25 No. 14 (2013): Vol 25 Issue 14

Issue Published : 8 August 2013

This work is licensed under a Creative Commons Attribution 4.0 International License.

Reductive Coupling of Aromatic Aldehydes and Acetophenone Induced by TiCl4-Al/CH2(COOEt)2

https://doi.org/10.14233/ajchem.2013.14890

Chang-Ying Song

Key Laboratory of Analytical Science and Technology, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei Province, P. R. China

Shu-Xiang Wang

Wen-Hao Chu

Ji-Tai Li

Zheng Zhou

Hong-Yu Li

Zi-Qing Cao

Corresponding Author(s) : Chang-Ying Song

scy@hbu.edu.cn

Asian Journal of Chemistry, Vol. 25 No. 14 (2013): Vol 25 Issue 14
Article Published : 12 August 2013

Abstract

Induced by TiCl₄-Al/CH₂(COOEt)₂ in CH₂Cl₂, some aromatic aldehydes and acetophenone can afford the corresponding 1,2-diols in 13-91 % yields with good dl-diastereoselectivities within 45-60 min at room temperature.

Keywords

Aromatic aldehydes Pinacol coupling Pinacol Low valent titanium Esters

(1)

Song, C.-Y.; Wang, S.-X.; Chu, W.-H.; Li, J.-T.; Zhou, Z.; Li, H.-Y.; Cao, Z.-Q. Reductive Coupling of Aromatic Aldehydes and Acetophenone Induced by TiCl4-Al CH2(COOEt)2. ajc 2013, 25, 7993-7996.