Synthesis and Fungicidal Activity of Novel Substituted Spiro-Heterocycles Derivatives

Abstract

Some spiro-heterocycles compounds have been synthesized by the piperidone hydrochloride, glycerol, aromatic acid, nicotinic acid and pyrazole acid. The target compounds were characterized by spectral data, including ¹H and ¹³C NMR, infrared, elemental analysis and mass spectra and were bioassayed in vitro against two kinds of phytopathogenic fungi i.e., B. cinerea and R. solani. The results showed that some of the synthesized spiro-heterocycles derivatives exhibited moderate antifungal activities, among which compounds b, e, h, j, k and q displayed more than 80 % inhibition activities against B. Cinerea. at 50 μg/mL, which was better than that of the commercial fungicides spiroxamine and hymexazol.