A Novel Four-Component Reaction Between a Secondary Amine and Salicylaldehyde with Isocyanide in Water

F. Gharakhani; E. Vessally; A. Mohammadi; Z. Alimadadi

doi:10.14233/ajchem.2013.15112

Issue

Vol. 25 No. 13 (2013): Vol 25 Issue 13

Issue Published : 17 July 2013

This work is licensed under a Creative Commons Attribution 4.0 International License.

A Novel Four-Component Reaction Between a Secondary Amine and Salicylaldehyde with Isocyanide in Water

https://doi.org/10.14233/ajchem.2013.15112

F. Gharakhani

Department of Chemistry, Miyaneh Branch, Islamic Azad University, Miyaneh, Iran

E. Vessally

Payame Noor University, Iran

A. Mohammadi

Payame Noor University, Iran

Z. Alimadadi

Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Corresponding Author(s) : E. Vessally

vessally@yahoo.com

Asian Journal of Chemistry, Vol. 25 No. 13 (2013): Vol 25 Issue 13
Article Published : 22 July 2013

Abstract

Reaction of isocyanide with iminium ion intermediate, formed by reaction between an electron deficit salicylaldehyde and a secondary amine in the presence of water proceeds smoothly at room temperature to afford benzo[b]furan derivatives (7) in high yields.

Keywords

Benzo[b]furan derivatives Three-component reaction Ugi reaction

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Gharakhani, F.; Vessally, E.; Mohammadi, A.; Alimadadi, Z. A Novel Four-Component Reaction Between a Secondary Amine and Salicylaldehyde With Isocyanide in Water. ajc 2013, 25, 7647-7648.