Antibacterial and Antifungal Activities of Bisbenzoylthiourea Compounds from Benzoyl Isothiocyanate and Diamines

Abstract

Five bisbenzoylthiourea compounds have been synthesized from benzoyl isothiocyanate and different diamines in CH₂Cl₂ medium under solid-liquid phase transfer catalysis conditions. Structures of these compounds have been characterized by elemental analyses as well as IR and ¹H NMR spectroscopy. These compounds were tested for their antibacterial and antifungal activities. The results indicated most of the compounds have good antimicrobial activities, especially in against agriculture disease fungal.