Antituberculosis and Antifungal Activities of Synthesized Benzoylthiourea Derivatives

Abstract

A series of benzoylthiourea derivatives have been synthesized from benzoyl isothiocyanate and phenyleneamine in CH₂Cl₂ medium under solid-liquid phase transfer catalysis conditions. Structures of these compounds have been characterized by elemental analyses as well as IR and ¹H NMR spectroscopy. All the compounds were tested for their antibacterial and antifungal activities, the results indicated that most of the compounds have antibacterial and antifungal activities close to the standard drugs, especially they were found to have remarkable antituberculosis and antifungal activities.