Laboratory of Investigation in Biological Science & Pharmacochemistry, FacultyofChemicalBiological Sciences, University Autonomic of Campeche, Av. Agustín Melgar, Col Buenavista C.P.24039 Campeche Cam., México
Francisco Diaz-Cedillo
Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, D.F. C.P. 11340, México
Elodia Garcia-Cervera
Laboratory of Investigation in Biological Science & Pharmacochemistry, FacultyofChemicalBiological Sciences, University Autonomic of Campeche, Av. Agustín Melgar, Col Buenavista C.P.24039 Campeche Cam., México
Eduardo Pool-Gomez
Laboratory of Investigation in Biological Science & Pharmacochemistry, FacultyofChemicalBiological Sciences, University Autonomic of Campeche, Av. Agustín Melgar, Col Buenavista C.P.24039 Campeche Cam., México
Abelardo Camacho-Luis
Facultad de Medicina de la Universidad Juárez del Estado de Durango, es Av. Fanny Anitua s/ n Esq. Av. Universidad. C.P. 34000, Durango, Dgo., México
Marcela Rosas-Nexticapan
Facultad de Nutrición, Universidad Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, México
Maria Lopez-Ramos
Laboratory of Investigation in Biological Science & Pharmacochemistry, FacultyofChemicalBiological Sciences, University Autonomic of Campeche, Av. Agustín Melgar, Col Buenavista C.P.24039 Campeche Cam., México
Ivan May-Gil
Laboratory of Investigation in Biological Science & Pharmacochemistry, FacultyofChemicalBiological Sciences, University Autonomic of Campeche, Av. Agustín Melgar, Col Buenavista C.P.24039 Campeche Cam., México
Ana Sarao-Alvarez
Laboratory of Investigation in Biological Science & Pharmacochemistry, FacultyofChemicalBiological Sciences, University Autonomic of Campeche, Av. Agustín Melgar, Col Buenavista C.P.24039 Campeche Cam., México
Carolina Naal-Dzib
Laboratory of Investigation in Biological Science & Pharmacochemistry, FacultyofChemicalBiological Sciences, University Autonomic of Campeche, Av. Agustín Melgar, Col Buenavista C.P.24039 Campeche Cam., México
Corresponding Author(s) : Lauro Figueroa-Valverde
lauro_1999@yahoo.com
Asian Journal of Chemistry,
Vol. 25 No. 12 (2013): Vol 25 Issue 12
In this study, two brucine derivative were synthetized; in first stage, the compound 1-{phenyl-[2-(2,3-dimethoxystrychnidin-10-yldeneamino)-ethylamino]-methyl}-naphtalen- 2-ol (4) was development by the reaction of b-naphthol, N1-(2,3-dimethoxystrychnidin-10-yliden)-ethane-1,2-diamine and benzaldehyde in ethanol. Also 4 was prepared by the reaction of brucine with 1-[(2-amino-ethylamino)-phenyl-methyl]-naphthalen-2-ol using as catalyst boric acid. In the second stage, the compound 4-hydroxy-N-[2-(2,3-dimethoxystrychnidin-10-ylideneamino)-ethyl]benzamide (8) was synthetized by the reaction of 4-hydroxybenzoic acid with N1-(2,3- dimethoxystrychnidin-10-yliden)-ethane-1,2-diamine using a carbodiimide derivative as catalyst. Finally, in other experiment the compound 8 was also prepared by the reaction of brucine with N-(2-aminoethyl)-4-hydroxybenzamide in presence of a carbodiimide derivative. The structure of all compounds obtained was confirmed by elemental analysis and spectroscopic methods.
Keywords
BrucineBoric acidβ-NaphtholCarbodiimide
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Figueroa-Valverde, L., Diaz-Cedillo, F., Garcia-Cervera, E., Pool-Gomez, E., Camacho-Luis, A., Rosas-Nexticapan, M., … Naal-Dzib, C. (2013). Design and Synthesis of Two Brucine Derivatives. Asian Journal of Chemistry, 25(12), 6783–6786. https://doi.org/10.14233/ajchem.2013.14674