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Design and Synthesis of Naphthol Derivative
Corresponding Author(s) : Lauro Figueroa-Valverde
Asian Journal of Chemistry,
Vol. 25 No. 12 (2013): Vol 25 Issue 12
Abstract
In this study a naphthalene derivative was synthetized using several strategies; in first stage a steroid derivative (3) was development by the reaction between androsterone and ethylenediamine using boric acid as catalyst. In the second stage compound 3 was used in the three-component system (b-naphthol, benzaldehyde and compound 3) for the synthesis of 17-(2-[[(2-hydroxy-n a p h t a l e n - 1 - y l ) - p h e n y l - m e t h y l ] a m i n o ] e t h y l a m i n o ) - 1 0 , 1 3 - d i m e t h y l - 2,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]-phenanthren-3-ol (6). In addition, a second method was used to form 6. In this technique 1-[(2-amino-ethylamino)-phenyl-methyl]-naphthalen-2-ol was made reacting with androsterone to form 6 using boric acid as catalyst. The structure of all compounds obtained was confirmed by spectroscopic and spectrometric methods.
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