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Synthesis of Thioxoquinazolin-4(3H)-one Derivatives Under Microwave and Ultrasonic Irradiation with Classical Heating
Corresponding Author(s) : DANAH S. AL-SHAMARY
Asian Journal of Chemistry,
Vol. 25 No. 12 (2013): Vol 25 Issue 12
Abstract
A series of thioxoquinazolin-4(3H)-one derivatives have been synthesized from hydrazide derivatives 1a-f using different electrophilic reagent, e.g., aryl isothiocyanate derivatives, carbon disulfide and aromatic aldehydes through nucleophilic substitution, condensation and cyclization reactions. Different methods were used to prepare compounds 2-6, including microwave irradiation, ultrasonic and classical heating. The compounds were characterized using various spectroscopic techniques. The synthesized compounds exhibited antibacterial activity.
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