Removal of Bacterial Endotoxin Micelle from Salvia Injection by Composite Materials Ultrafiltration Membrane

Abstract

Bacterial endotoxins (BEs) produce a fever-like effect on humans upon entry into the blood system even at extremely low concentration. Bacterial endotoxins possess surface activity and their monomers can be found in aggregate micelle forms. These aggregate micelles could be dispersed onto the surface of polyethersulfone ultrafiltration membranes during removal of bacterial endotoxins from injections, and the loss of several drug active ingredients, such as salvianolic acid B, is significant. The proper balance between bacterial endotoxin rejection and active ingredient retention has not been fully elucidated. The results of this study show that the composite polymer decreased the interaction between the micelles and the membrane, resulting in the prevention and rejection of aggregated bacterial endotoxin and the loss of salvianolic acid B by less than 5 %. Determination of the interface interaction between the bacterial endotoxin micelles and the membrane materials will significantly improve the removal of bacterial endotoxin from injections with suitable membrane molecular weight cut off.