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Passive Mixer and Separator Integrated on a Ceramic-Based Microfluidic Device
Corresponding Author(s) : Young Joon Yoon
Asian Journal of Chemistry,
Vol. 25 No. 10 (2013): Vol 25 Issue 10
Abstract
A ceramic-based microfluidic device including a passive mixer and a passive separator was fabricated via a conventional low temperature co-fired ceramic process and photolithographic technique. In the mixing process, the configuration of a conventional diffusion-type passive mixer with a 500 μm channel width and 50 μm height was used. The total length of the mixing channel was 15.8 cm. The maximum mixing efficiency of the diffusion-type passive mixer was 97.3 % at a flow rate of 0.3 μL/min. In the separation process, six branch channels were arranged at the end of the pinched segment for separating different sized particles from one another. The findings confirmed that microbeads for a target channel were separated efficiently by controlling the hydrodynamic conditions of the microfluids.
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- M. Chudy, I. Grabowska, A.F.- Szymanska, D. Stadnik, I. Wyzkiewicz, P. Ciosek, E. Jedrych, M. Juchniewicz, M. Skolimowski, K. Ziolkowska and R. Kwapiszewski, Anal. Bioanal. Chem., 395, 647 (2009).
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- M.R. Gongora-Rubio, M.B.A. Fontes, Z.M. da Rocha, E.M. Richter and L. Angnes, Sens. Actuators B, 103, 468 (2004).
- P. Bembnowicz and L.J. Golonka, J. Eur. Ceram. Soc., 30, 743 (2010).
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- O. Shardt, S.K. Mitra and J.J. Derksen, Chem. Eng. Sci., 75, 106 (2012).
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References
M. Chudy, I. Grabowska, A.F.- Szymanska, D. Stadnik, I. Wyzkiewicz, P. Ciosek, E. Jedrych, M. Juchniewicz, M. Skolimowski, K. Ziolkowska and R. Kwapiszewski, Anal. Bioanal. Chem., 395, 647 (2009).
M. Yamada and M. Seki, Anal. Chem., 76, 895 (2004).
S. Badilescu and M. Packirisamy, Polymers, 4, 1278 (2012).
J. Chen, J. Li and Y. Sun, Lab. Chip, 12, 1753 (2012).
R. Guldiken, M. Chan Jo, N.D. Gallant, U. Demirci and J. Zhe, Sensors, 12, 905 (2012).
W.L. Zhang and R.E. Eitel, Int. J. Appl. Ceram. Technol., 9, 60 (2012).
M.R. Gongora-Rubio, M.B.A. Fontes, Z.M. da Rocha, E.M. Richter and L. Angnes, Sens. Actuators B, 103, 468 (2004).
P. Bembnowicz and L.J. Golonka, J. Eur. Ceram. Soc., 30, 743 (2010).
M. Wu and R.A. Yetter, J. Micromech. Microeng., 18, 125016 (2008).
M.A. Ansari, K. Kim, K. Anwar and S.M. Kim, J. Micromech. Microeng., 20, 055007 (2010).
O. Shardt, S.K. Mitra and J.J. Derksen, Chem. Eng. Sci., 75, 106 (2012).
J. Takagi, M. Yamada, M. Yasuda and M. Seki, Lab Chip, 5, 778 (2005).
J. Choi, Y.J. Yoon, Y.-S. Choi, H.T. Kim, J. Kim, J.-H. Lee and J.-h. Kim, J. Ceram. Proc. Res., 12, 146 (2011)