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Vol. 25 No. 10 (2013): Vol 25 Issue 10

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Antioxidant, Antibacterial and Antiproliferative Activities of Areal Parts of Swertia chirata (Bush Ham) Plant Extracts Using In Vitro Models

https://doi.org/10.14233/ajchem.2013.14700
Syed Ali Raza Naqvi
Department of Chemistry, Government College University, Faisalabad-38000, Pakistan
Qurat-Ul- Ain
Department of Chemistry, Government College University, Faisalabad-38000, Pakistan
Zulfiqar Ali Khan
Department of Chemistry, Government College University, Faisalabad-38000, Pakistan
Zaib Hussain
Institute of Chemistry, University of the Punjab, Lahore-54000, Pakistan
Sohail Anjum Shahzad
Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan
Muhammad Yar
Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore-54000, Pakistan
Abdul Ghaffar
Department of Chemistry, Government College University, Faisalabad-38000, Pakistan
Nasir Mahmood
Department of Allied Health Sciences, University of Health Sciences, Lahore-54000, Pakistan
Samina Kousar
Institute of Chemistry, University of the Punjab, Lahore-54000, Pakistan

Corresponding Author(s) : Syed Ali Raza Naqvi

a_ naqvi313@yahoo.com

Asian Journal of Chemistry, Vol. 25 No. 10 (2013): Vol 25 Issue 10

Abstract

Ariel parts of Swertia chirata was investigated for its medicinal values. Like many other plants and herbs, Swertia chirata has also been used for treating diseases particularly liver disorder. Anti-disease functions of most of the plants or herbs extracts have been associated with antioxidant and antibacterial potential. This study was performed to explore the antioxidant and antibacterial activity of the Swertia chirata (Bush ham). This was done by measuring possible constituents responsible for its antioxidant activity such as total phenolic and flavonoid contents. Antioxidant potential was measured using authentic in vitro assay models such as DPPH free radical scavenging assay and per cent inhibition of linoleic acid peroxide. The antibacterial and antiproliferative activity was measured against four different strains of gram positive and gram negative bacteria and MDBK cancer cell line, respectively. Promising concentration of total phenolics and flavonoids resulted encouraging DPPH free radical scavenging (84.32 ± 2.78 and 82.54 ± 3.12 %) and linoleic acid peroxide inhibition (94.04 ± 4.23 and 92.86 ± 4.78 %) and consequently credible antioxidant potential. Antibacterial and antiproliferative data of extracts indicated Swertia chirata might be a good member for fighting against infectious and chronic diseases.

Keywords

Antioxidants Swertia chirata HPLC Antibacterial activity Total phenolics Free radical scavenging
Ali Raza Naqvi, S., Ain, Q.-U.-., Ali Khan, Z., Hussain, Z., Anjum Shahzad, S., Yar, M., … Kousar, S. (2013). Antioxidant, Antibacterial and Antiproliferative Activities of Areal Parts of Swertia chirata (Bush Ham) Plant Extracts Using In Vitro Models. Asian Journal of Chemistry, 25(10), 5448–5452. https://doi.org/10.14233/ajchem.2013.14700
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