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Vol. 25 No. 10 (2013): Vol 25 Issue 10

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Chitosan-Gelatin-Pectin Composite Films from Polyion-Complex Hydrogels

https://doi.org/10.14233/ajchem.2013.14193
X.F. Zheng
School of Physics and Chemistry, Hebei Normal University of Science and Technology, Qinhuangdao 066600, P.R. China
Q. Lian
School of Physics and Chemistry, Hebei Normal University of Science and Technology, Qinhuangdao 066600, P.R. China
S.T. Song
School of Physics and Chemistry, Hebei Normal University of Science and Technology, Qinhuangdao 066600, P.R. China

Corresponding Author(s) : X.F. Zheng

xuefang-zheng@163.com

Asian Journal of Chemistry, Vol. 25 No. 10 (2013): Vol 25 Issue 10

Abstract

Preparation and properties of composite films from gelatin, chitosan and pectin hydrogels are presented. Ionic interactions between positively charged gelatin and negatively charged pectin produce reversible physical hydrogels with homogeneous molecular arrangement that improve water resistance but not alter thermal stability relative to single polymer gels. The effect of preparation conditions to the swelling rate and drug delivery of chitosan-gelatin-pectin films were also studied. Resulting interspersed permanent chemical hydrogel showed a decreased swelling attitude with the increased dosage of crosslinker. However, further the films improved higher permeation in simulated colonic fluid compared to the other media. The amount of bovine serum albumin released from the films at different time intervals was estimated by UV spectrophotomertic method at 279 nm. The dissolution profile and in vitro release kinetics showed that chitosan-gelatin-pectin films were promising for controlled delivery of the drug. Formulation containing pectin, chitosan and gelatin may be suitable as a coating formulation for colon targeted drug delivery.

Keywords

Pectin Composite films Swelling rate Bovine serum albumin Colonic delivery
Zheng, X., Lian, Q., & Song, S. (2013). Chitosan-Gelatin-Pectin Composite Films from Polyion-Complex Hydrogels. Asian Journal of Chemistry, 25(10), 5363–5366. https://doi.org/10.14233/ajchem.2013.14193
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References
  1. R.N. Tharanthan, Trends Food Sci. Technol., 14, 71 (2003).
  2. C.C. Lin and A.T. Metters, Adv. Drug Delivery Rev., 58, 1379 (2006).
  3. A. Khademhosseini and R. Langer, Biomater., 28, 5087 (2007).
  4. S.Y. Ong, J. Wu, S.M. Moochhala, M.H. Tan and J. Lu, Biomater., 29, 4323 (2008).
  5. A. Ghaffari, K. Navaee, M. Oshoui, K. Bayati and M. Rafiee-Tehrani, Eur. J. Pharm. Biopharm., 67, 175 (2007).
  6. X. Wei, N. Sun, B. Wu, C. Yin and W. Wu, Int. J. Pharm., 318, 132 (2006).
  7. A.S. Hoffiman, P.S. Stayton, O. Press, N. Murthy, C.A. Lackey and C. Cheung, Polym. Adv. Technol., 13, 992 (2002).
  8. D. Myung, D. Waters, M. Wiseman, P.E. Duhamel, J. Noolandi and C.N. Ta, Polym. Adv. Technol., 19, 647 (2008).
  9. N.A. Peppas, Pharm. Acta Helv., 60, 110 (1985).
  10. E. Ojoe, E.M. Miyauchi, T.C. Viviani and V.O. Consiglieri, Braz. J. Pharm. Sci., 41, 377 (2005).
  11. G.R. Bardajee, A. Pourjavadi and R. Soleyman, Nucl. Instrum. Methods Phs. Res. A, 266, 3932 (2008).
  12. S.B. Teli, G.S. Gokavi and T.M. Aminabhavi, Sep. Purif. Technol., 56, 150 (2007).
  13. A. Pourjavadi, H. Ghasemzadeh and R. Soleyman, J. Appl. Polym. Sci., 105, 813 (2007).
  14. L.B. Peppas, Med. Plast. Biomater., 4, 34 (1997).
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