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Preparation and Reaction of Fluorescently-Labeled Chitosan Nano Particles
Corresponding Author(s) : Hong Sun
Asian Journal of Chemistry,
Vol. 25 No. 10 (2013): Vol 25 Issue 10
Abstract
Chitosan nano particles were prepared firstly through the electrostatic interaction between chitosan polycation and sodium tripolyphosphate and then fluorescently-labeled chitosan nano particles was made by the reaction between the primary amino group (2-NH2) of chitosan and isothiocyanate root (N=C=S) of fluorescein isothiocyanate. Finally the effects of reaction time and chitosan concentration on the fluorescence labeling efficiency of chitosan were discussed. The results showed that various reaction times and chitosan concentrations had great effects on the structure and fluorescence labeling efficiency of chitosan nano particles.
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- A.N. Ferguson and A.G. O'Neill, Focus on Chitosan Research, Nova Science Publishers, ISBN 978-1-62081-841-1 (2011).
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- C.Q. Tan and Y.M. Du, J. Xiaogan Univ., 22, 5 (2002).
References
A.N. Ferguson and A.G. O'Neill, Focus on Chitosan Research, Nova Science Publishers, ISBN 978-1-62081-841-1 (2011).
G.L. Martin, J.A. Ross, S.D. Minteer, D.M. Jameson and M.J. Cooney, Carbohyd. Polym., 77, 695 (2009).
C. Li, K. Yang, Y. Zhang, H. Tang, F. Yan, L. Tan, Q. Xie and S. Yao, Acta Biomater., 7, 3070 (2011).
M. Huang, Z. Ma, E. Khor and L.Y. Lim, Pharm. Res., 19, 1488 (2002).
C.Q. Tan and Y.M. Du, J. Xiaogan Univ., 22, 5 (2002).