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Vol. 29 No. 2 (2017): Vol 29 Issue 2

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Synthesis, Characterization and Antiproliferative Activity of Certain Meclofenamic Acid Amides

https://doi.org/10.14233/ajchem.2017.20165
Tilal Elsaman
Department of Pharmaceutical Chemistry, College of Pharmacy, Omdurman Islamic University, P.O. Box 2587, Khartoum, Sudan
Omar A. Al-Deeb
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Tarek Aboul-Fadl
Department of Medicinal Chemistry, College of Pharmacy, Assiut University, Assiut 71526, Egypt

Corresponding Author(s) : Tilal Elsaman

tilochem@yahoo.com

Asian Journal of Chemistry, Vol. 29 No. 2 (2017): Vol 29 Issue 2

Abstract

Synthesis of new meclofenamic acid amide derivatives is reported using various amino acid esters and dicyclohexylcarbodiimide as coupling agent. All of the synthesized compounds were characterized by their FT-IR, 1H NMR, 13C NMR and mass spectral data. The antiproliferative activity against human adenocarcinoma cell line HT29 was determined. Compounds 3, 4, 6, 7, 9, 10 and 11 displayed excellent inhibitory activity compared to the parent drug. Of these seven initial hits, compound 7 was the most active.

Keywords

NSAIDs Meclofenamic acid Colorectal cancer Chemoprevention
Elsaman, T., Al-Deeb, O. A., & Aboul-Fadl, T. (2016). Synthesis, Characterization and Antiproliferative Activity of Certain Meclofenamic Acid Amides. Asian Journal of Chemistry, 29(2), 291–295. https://doi.org/10.14233/ajchem.2017.20165
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