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Vol. 29 No. 2 (2017): Vol 29 Issue 2

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Comparative Study of Microwave Assisted and Conventional Synthesis of Furfuraldehyde Based Hydrazone Derivatives and their Metal Complexes with Biological Evaluation

https://doi.org/10.14233/ajchem.2017.20232
Mussarat Jabeen
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan
Karamat Mehmood
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan
Misbahul Ain Khan
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan
Muhammad Nasrullah
Department of Chemistry, University of Sargodha, Women Campus, Faisalabad 38000, Pakistan
Tahir Maqbool
Department of Chemistry, Government College University, Faisalabad 38000, Pakistan
Farhat Jabeen
Government Degree College (Women), Yazman 63210, Pakistan
Misbah Afzal
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

Corresponding Author(s) : Tahir Maqbool

tahirmakbool@gmail.com; chemiub14@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 2 (2017): Vol 29 Issue 2

Abstract

A series of acyl hydrazone derivatives were synthesized by the condensation of different hydrazides (benzohydrazide, isoniazid, nicotinic acid hydrazide and salicylhydrazide) and 5-(4'-nitrophenyl) furan-2-carbaldehyde. These hydrazones were subjected for metal complexation to yield copper(II) and nickel(II) complexes using conventional and microwave irradiation method. The microwave method was found to be successful with nearly the same or higher yields and shorter reaction time. The synthesized compounds were characterized by EIMS, CHN analysis, FTIR and NMR spectroscopy. All the synthesized compounds were screened for their antibacterial and antioxidant activities.

Keywords

Furfuraldehyde Benzohydrazide Isoniazid Nicotinic acid hydrazide Salicylhydrazide Antibacterial Antioxidant
Jabeen, M., Mehmood, K., Khan, M. A., Nasrullah, M., Maqbool, T., Jabeen, F., & Afzal, M. (2016). Comparative Study of Microwave Assisted and Conventional Synthesis of Furfuraldehyde Based Hydrazone Derivatives and their Metal Complexes with Biological Evaluation. Asian Journal of Chemistry, 29(2), 431–436. https://doi.org/10.14233/ajchem.2017.20232
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