Synthesis, Characterization and Antimicrobial Studies of Coordination Compounds of L-Serine and their Mixed Ligand Complexes with L-Aspartic Acid

O.E. Olasomi; O.F. Akinyele; E.O. Akinkunmi; D.A. Isabirye; T.O. Aiyelabola

doi:10.14233/ajchem.2017.20203

Issue

Vol. 29 No. 2 (2017): Vol 29 Issue 2

Issue Published : November 30, 2016

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization and Antimicrobial Studies of Coordination Compounds of L-Serine and their Mixed Ligand Complexes with L-Aspartic Acid

https://doi.org/10.14233/ajchem.2017.20203

O.E. Olasomi

Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria

O.F. Akinyele

Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria

E.O. Akinkunmi

Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Nigeria

D.A. Isabirye

Department of Chemistry, North West University, Mafikeng Campus, South Africa

T.O. Aiyelabola

Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria

Corresponding Author(s) : T.O. Aiyelabola

tt1haye@yahoo.com

Asian Journal of Chemistry, Vol. 29 No. 2 (2017): Vol 29 Issue 2
Article Published : December 9, 2016

Abstract

The coordination complexes of Co(II), Ni(II) and Cu(II) with L-serine and its mixed ligand with L-aspartic acid were synthesized and characterized. The compounds were characterized using UV-visible, infrared spectra and metal analyses. Antimicrobial study of the complexes was carried out, the tested microbes included two Gram-positive and five Gram-negative bacteria and one fungus. The results suggested an octahedral geometry for the complexes with L-aspartic acid and L-serine acting as tridentate ligands. The ligands coordinated with the metal ions through N and O donor atoms respectively. The antimicrobial study showed the complexes possess activity against the micro-organisms.

Keywords

L-Serine L-Aspartic acid Mixed ligand complexes Antimicrobial activity Metal(II) ion

Olasomi, O., Akinyele, O., Akinkunmi, E., Isabirye, D., & Aiyelabola, T. (2016). Synthesis, Characterization and Antimicrobial Studies of Coordination Compounds of L-Serine and their Mixed Ligand Complexes with L-Aspartic Acid. Asian Journal of Chemistry, 29(2), 371–374. https://doi.org/10.14233/ajchem.2017.20203

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References

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References

A. Romerosa, P. Bergamini, V. Bertolasi, A. Canella, M. Cattabriga, R. Gavioli, S. Mañas, N. Mantovani and L. Pellacani, Inorg. Chem., 43, 905 (2004).

S. Rafique, M. Idrees, A. Nasim, H. Akbar and A. Athar, Biotechnol. Mol. Biol. Rev., 5, 38 (2010).

E. Farkas, É.A. Enyedy, G. Micera and E. Garribba, Polyhedron, 19, 1727 (2000).

H. Sigel and D.B. McCormick, J. Am. Chem. Soc., 93, 2041 (1971).

D.L. Stone, D.K. Smith and A.C. Whitwood, Polyhedron, 23, 1709 (2004).

B. Saleema and G. Parameswaean, Asian J. Chem., 15, 1491 (2003).

S. Bunel, G. Larrazabal and A. Decinti, J. Inorg. Nucl. Chem., 43, 871 (1981).

A.S. Bodkhe, S.S. Patil and M.M. Shaikh, Acta Pol. Pharm.-Drug Res., 69, 871 (2012).

P.R. Murray, E.J. Baroon, M.A. Pfaller, F.C. Tenover and R.H. Yolke, Manual of Clinical Microbiology, American Society for Microbiology, Washington, DC, edn 6, pp. 56-77 (1995).

G.L. Miessler and D.A. Tarr, Coordination Compounds, In: Inorganic Chemistry, Pearson Prentice Hall, New York, p. 642, pp. 315-316 (1999).

K. Nakamoto, Complexes of Amino Acids; In: Infrared and Raman Spectra of Inorganic and Coordination Compounds, Wiley Interscience, New York, edn 6, pp. 66-74 (2009).

N.N. Greenwood and A. Earnshaw, Coordination Compounds, In: Chemistry of the Elements, Oxford, Butterworth-Heinemann, Hong Kong, edn 2, pp. 1060-1090, 1290-1326 (1997).

A. Thakur, Principle, Working and Applications of UV Spectroscopy (2011).

Z.H. Chohan, Appl. Organomet. Chem., 16, 17 (2002).

Z.H. Chohan, M. Arif, Z. Shafiq, M. Yaqub and C.T. Supuran, J. Enzyme Inhib. Med. Chem., 21, 95 (2006).

Issue

Vol. 29 No. 2 (2017): Vol 29 Issue 2

Synthesis, Characterization and Antimicrobial Studies of Coordination Compounds of L-Serine and their Mixed Ligand Complexes with L-Aspartic Acid

Corresponding Author(s) : T.O. Aiyelabola

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