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Vol. 33 No. 8 (2021): Vol 33 Issue 8, 2021

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Antibacterial and Antitubercular Activity of Novel Benzothiazole-Aryl Amine Derivatives Tethered through Acetamide Functionality

https://doi.org/10.14233/ajchem.2021.23226
Farhana Hakim
Department of Chemistry, Career Point University, Kota-325003, India
S. Roshan Salfidoer
Department of Chemistry, Career Point University, Kota-325003, India

Corresponding Author(s) : S. Roshan Salfidoer

roshansalfi86@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 8 (2021): Vol 33 Issue 8, 2021

Abstract

A novel series of substituted benzothiazole-N-phenyl acetamides were synthesized through a feasible scheme and characterized by IR, 1H NMR and mass spectral methods. All the synthesized compounds were screened for antibacterial activity against two, Gram-positive strains: Staphylococcus aureus, Bacillus subtilis; four, Gram-negative strains: Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa and Klebsiella pneumonia; and antitubercular activity against mycobacterial strain: Mycobacterium tuberculosis. Among the 15 compounds (6a-o) tested, three compounds 6e, 6l and 6m have demonstrated high potency with MIC values ranges from 6.25-12.5 μg/mL against both Gram-positive and Gram-negative strains. Compounds 6e and 6l displayed remarkable antitubercular activity with MIC value of 25 μg/mL.

Keywords

Benzothiazole Acetamide Antibacterial activity Antitubercular activity
Hakim, F., & Roshan Salfidoer, S. (2021). Antibacterial and Antitubercular Activity of Novel Benzothiazole-Aryl Amine Derivatives Tethered through Acetamide Functionality. Asian Journal of Chemistry, 33(8), 1757–1763. https://doi.org/10.14233/ajchem.2021.23226
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