Concentration and Temperature Dependence of the Thermodynamic Properties of Novel Biologically Active 3-Substituted Schiff Base of 4-Piperidyl N-(4-chlorophenyl)maleimide

Abstract

In present work, the concentration and temperature dependence of the thermodynamic properties of 3-substituted Schiff base of 4-piperidyl N-(4-chlorophenyl)maleimide compound in 80% DMSO was estimated. Concentration (0.002-0.01 M) and temperature (298-313 K) dependent densitometric and viscometric measurement were employed to evaluate limiting molar volume (f_v⁰), semi-empirical parameter (Sv), Falkenhagen (A) and Jones-Dole (B) viscosity coefficient. The obtained results suggest the presence of weaker solute-solvent interactions and stronger solute-solute interactions. It was observed that these interactions strongly depend on the temperature of the system. Furthermore, the Gibbs free energy (ΔG), enthalpy (ΔH) and entropy (ΔS) of the system were also evaluated. The negative values of ΔG and ΔH and positive values of ΔS indicating reaction was spontaneous and exothermic in nature.