Synthesis, Spectral Characterization and Biological Evaluation of Metal Complexes of 2-Thioxoquinoline Aminophenol

Abstract

A series of novel 2-thioxoquinoline aminophenol Schiff base based Co(II), Ni(II), Cu(II) and Zn(II) metal complexes [M(L)₂], (M = Co²⁺, Ni²⁺, Cu²⁺ & Zn²⁺; L = 2-thioxoquinoline aminophenol) were synthesized and characterized by elemental analysis and spectral studies (FT-IR, UV-Vis, ¹H NMR, ESR and ESI-Mass). All experimental results showed that in these metal complexes, the central metal atom was coordinated by oxygen, nitrogen and sulfur donor atoms of deprotonated Schiff base. Further, the ligand and its metal(II) complexes were screened against Gram-positive (Staphylococcus aureus), Gram-negative (Escherichia coli) bacteria and fungus (Candida albicans) strains. in vitro Anticancer activity of ligand and its metal(II) complexes were also screened against HeLa cells (Human cervical cancer cells).