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Vol. 33 No. 6 (2021): Vol 33 Issue 6, 2021

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Emerging Potential of Metallodrugs to Target Coronavirus: Efficacy, Toxicity and their Mechanism of Action: A Review

https://doi.org/10.14233/ajchem.2021.23228
Ashu Chaudhary
Department of Chemistry, Kurukshetra University, Kurukshetra-136119, India
Pinki
Department of Chemistry, Kurukshetra University, Kurukshetra-136119, India
Subhash
Department of Chemistry, Kurukshetra University, Kurukshetra-136119, India

Corresponding Author(s) : Ashu Chaudhary

ashuchaudhary21@gmail.com, ashuchaudhary@kuk.ac.in

Asian Journal of Chemistry, Vol. 33 No. 6 (2021): Vol 33 Issue 6, 2021

Abstract

On eleventh March 2020, the contagion of the novel COVID-19 was announced by the WHO. Right now, there are no new enlisted medications that can viably cure the COVID-19 contagion. Some recently utilized drugs and combinations with their harmfulness profiles have been contemplated. The frequently announced poisonous impacts of these medicines, for example, hepatotoxicity, retinal harm, nephrotoxicity and cardiotoxicity. One of the most broadly examined drugs is favipiravir. The surface collaboration of favipiravir with organometallic composites came about by doping of transition metals of first row of the periodic table was analyzed to choose the most reasonable metallofullerenes for COVID-19 treatment. Some acknowledged pharmacophore edifices of bioactive constituents can be valuable in the explanation of against SARS-CoV-2 particulars. The advantage of utilizing arrangements encompassing phytochemicals is their sky-scraping wellbeing for ill persons and no negative reaction. Iron oxide nanoparticles (IONPs) were recently affirmed by the USFDA for anaemia therapy and variations have additionally exhibited its effectiveness against viruses in vitro for COVID-19. The adequacy of the Zn2+ salt enhancement could likewise be improved with Nigella sativa as its major bioactive segment would fill in as ionophore to permit Zn2+ to enter pneumocytes-the objective cell for the coronavirus (COVID-19). This review article depicts the utilization of medications, their usefulness and their harmful impacts for COVID-19 patients.

Keywords

SARS-CoV-2 Iron oxide nanoparticles Metallofullerenes Nigella sativa Phytochemicals
Chaudhary, A., Pinki, ., & Subhash, . (2021). Emerging Potential of Metallodrugs to Target Coronavirus: Efficacy, Toxicity and their Mechanism of Action: A Review. Asian Journal of Chemistry, 33(6), 1191–1207. https://doi.org/10.14233/ajchem.2021.23228
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