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Vol. 32 No. 2 (2020): Vol 32 Issue 2

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Synthesis, Characterization and Anticancer Activity of Transition Metal Substituted Polyoxometalate-β-Cyclodextrin Composites

https://doi.org/10.14233/ajchem.2020.22321
Bharath Samannan
Department of Chemistry, Sacred Heart College, Tirupattur-635601, India
Jothi Selvam
Department of Chemistry, Sacred Heart College, Tirupattur-635601, India
Jeyabalan Thavasikani
Department of Chemistry, Sacred Heart College, Tirupattur-635601, India

Corresponding Author(s) : Jeyabalan Thavasikani

jayabalandr@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 2 (2020): Vol 32 Issue 2

Abstract

A novel hybrid composite, namely {[VIV+PMo11O40]⊂[β-CD]} which shows the high percent of apoptosis of MTT assay of A549 cell line (lung cancer) in different concentrations. The composite has been characterized using techniques such as FT-IR, EPR, SEM, EDS and X-ray diffraction. The anticancer (lung cancer A549 cell line) was investigated using direct microscopic observations for drug treated cell line and IC50 value of 1.93. The apoptosis of 45.37 % cell death in cell line of minimum concentration (3.12 μg/mL) shows the good viability of β-CD-POM against lung cancer A549 cell line.

Keywords

Anticancer β-Cyclodextrin Hybrid composite Polyoxometalate
Samannan, B., Selvam, J., & Thavasikani, J. (2019). Synthesis, Characterization and Anticancer Activity of Transition Metal Substituted Polyoxometalate-β-Cyclodextrin Composites. Asian Journal of Chemistry, 32(2), 297–302. https://doi.org/10.14233/ajchem.2020.22321
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