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Vol. 32 No. 2 (2020): Vol 32 Issue 2

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NbCl5 and AgClO4 Promoted Regio-Selective Acylation of Indoles

https://doi.org/10.14233/ajchem.2020.22419
Narendra R. Kamble
Department of Chemistry, PDEA′s Waghire College, Saswad-412301, India
https://orcid.org/0000-0001-8274-8204
Hari R. Pawar
Department of Chemistry, MES′s Abasaheb Garware College, Karve Road, Pune-411004, India
Vinod T. Kamble
Organic Chemistry Research Laboratory, Department of Chemistry, Institute of Sciences, Nagpur- 440008, India

Corresponding Author(s) : Narendra R. Kamble

narendra1499@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 2 (2020): Vol 32 Issue 2

Abstract

In present study, an efficient and simple strategy towards chemo-selective and regio-selective acylation of indole using NbCl5 and AgClO4 catalyst are reported. This method utilizes the catalytic potentiality of NbCl5 and AgClO4 towards acylation of unprotected indoles in a synergistic manner. The combination of these catalytic system results into numerous advantages such as excellent yields of product, short reaction times and easier isolation of products.

Keywords

Regioselective acylation Silver salt Indole Acyl chloride
Kamble, N. R., Pawar, H. R., & Kamble, V. T. (2019). NbCl5 and AgClO4 Promoted Regio-Selective Acylation of Indoles. Asian Journal of Chemistry, 32(2), 317–321. https://doi.org/10.14233/ajchem.2020.22419
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