Metasystox Induced Alteration in Nucleic Acid and Protein levels of Rat Brain

Abstract

The level of DNA, RNA and Protein were estimated in cerebral hemisphere, cerebellum, brain stem and spinal cord of male albino rats with Metasytox (0, 0, dimethyl-S-2 ethylsulphinyl) 4 mg/kg body weight intraperitoneally (ip) daily for 10 days. The daily ip dose of Metasystox depleted the level of DNA in all brain regions, Whereas the level of RNA was decreased in cerebrum and increased in rest of the brain parts. Increased level of protein was observed in cerebral hemisphere while the level decreased in cerebellum, brain stem and spinal cord.