Synthesis and Characterization ofBiologically Active Organotin-Platinum-Imine and Organotin-Platinum-Amine Complexes

Abstract

¹H, ¹³C and ³¹P-chemical shifts are reported for the first time for new biologically active organotin-imine, organotin-amine ligand. and their complexes with platinum(II), complexes of the type trans-[PtCl₂(PPh₃)(imine)] and trans[ PtCl₂(PPh₃(amine)], the imine ligand being derived from 3-[tri-n-butylstannyl)benzaldehyde and primary amines; the amine ligand obtained by the reduction of the appropriate imine. The use of multinuclear spectroscopy provides strong evidence for structure determination of these complexes. Of interest is that both ¹H and ¹³C resonances of CH=N and ¹³C of R-carbon data (γ-protons and β-carbons to the platinum atom), exhibit large downfield shifts upon coordination of imine (or amine) with respect to free imine (or amine). In addition, ¹H, ¹³C and ³¹P-NMR spectra show that only a single rotamer exists.