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Synthesis, Characterization and Docking Studies of Anti-HCV Molecules
Corresponding Author(s) : Satish Kumar
Asian Journal of Chemistry,
Vol. 32 No. 5 (2020): Vol 32 Issue 5
Abstract
The present study reports the synthesis and characterization of novel molecules inhibiting the spread of hepatitis C. The molecules were designed as to block the NS3/4A protease enzyme on HCV RNA. The molecules were synthesized using usual peptide synthesis techniques. Compounds with purity more than 95% were characterized and docking studies were also performed. All the compounds were characterized using physico-chemical techniques such as determination of melting point by DSC and NMR, mass, IR spectral studies. The docking studies were also conducted to assess the activity of molecules for inhibition of hepatitis C virus.
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- N.M.O. Da-Silva and R. Do-Carmo Zanella, J. Preven. Infect. Control, 2, 16 (2016).
- P. Simmonds, J. Hepatol., 31, 54 (1999); https://doi.org/10.1016/S0168-8278(99)80375-4
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- N.N. Zein, Clin. Microbiol. Rev., 13, 223 (2000); https://doi.org/10.1128/CMR.13.2.223
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- I. Gentile, F. Borgia, A.R. Buonomo, G. Castaldo and G. Borgia, Curr. Med. Chem., 20, 3733 (2013); https://doi.org/10.2174/09298673113209990178
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- J. Levin, Presented at 63rdAnnual Meeting of the American Association for the Study of Liver diseases Boston, MA: USA, November 9-12 (2012).
- S. Pol, A. Vallet-Pichard and M. Corouge, Hepat. Med., 8, 21 (2016); https://doi.org/10.2147/HMER.S62014
- S.L. Tan, Hepatitis C Viruses: Genomes and Molecular Biology, Norfolk: UK, pp 6/163-6/206 (2006).
- J.-M. Pawlotsky, Gastroenterology, 140, 746 (2011); https://doi.org/10.1053/j.gastro.2011.01.028
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References
N.M.O. Da-Silva and R. Do-Carmo Zanella, J. Preven. Infect. Control, 2, 16 (2016).
P. Simmonds, J. Hepatol., 31, 54 (1999); https://doi.org/10.1016/S0168-8278(99)80375-4
L.E. Dowsett, S. Coward, D.L. Lorenzetti, G. MacKean and F. Clement, Can. J. Gastroenterol. Hepatol., 2017, 3268650 (2017); https://doi.org/10.1155/2017/3268650
P. Simmonds, J. Bukh, C. Combet, G. Deléage, N. Enomoto, S. Feinstone, P. Halfon, G. Inchauspé, C. Kuiken, G. Maertens, M. Mizokami, D.G. Murphy, H. Okamoto, J.M. Pawlotsky, F. Penin, E. Sablon, T. Shin-I, L.J. Stuyver, H.J. Thiel, S. Viazov, A.J. Weiner and A. Widell, Hepatology, 42, 962 (2005); https://doi.org/10.1002/hep.20819
N.N. Zein, Clin. Microbiol. Rev., 13, 223 (2000); https://doi.org/10.1128/CMR.13.2.223
H. Singh, H.K. Bhatia, N. Grewal and N.K. Natt, J. Pharmacol. Pharmacother., 5, 278 (2014); https://doi.org/10.4103/0976-500X.142464
I. Gentile, F. Borgia, A.R. Buonomo, G. Castaldo and G. Borgia, Curr. Med. Chem., 20, 3733 (2013); https://doi.org/10.2174/09298673113209990178
Y. Wei, J. Li, J. Qing, M. Huang, M. Wu, F. Gao, D. Li, Z. Hong, L. Kong, W. Huang and J. Lin, PLoS One, 11, e0148181 (2016); https://doi.org/10.1371/journal.pone.0148181
J. Levin, Presented at 63rdAnnual Meeting of the American Association for the Study of Liver diseases Boston, MA: USA, November 9-12 (2012).
S. Pol, A. Vallet-Pichard and M. Corouge, Hepat. Med., 8, 21 (2016); https://doi.org/10.2147/HMER.S62014
S.L. Tan, Hepatitis C Viruses: Genomes and Molecular Biology, Norfolk: UK, pp 6/163-6/206 (2006).
J.-M. Pawlotsky, Gastroenterology, 140, 746 (2011); https://doi.org/10.1053/j.gastro.2011.01.028
S.L. Flamm, P.J. Pockros, L. Bengtsson and M. Friedman, J. Clin. Transl. Hepatol., 2, 65 (2014); https://doi.org/10.14218/JCTH.2014.00007