Condensation of Aryl Benzyl Ketones with Dimethyl-β,β- Dimethyl-Glutarate. Synthesis of (Z)- and (E)-5-aryl- 4-Carbomethoxy-3,3-Dimethyl-6-Phenyl-hex-4-Enoic Acids
Corresponding Author(s) : Fakhry Abdel-Aziz El-Bassiouny
Asian Journal of Chemistry,
Vol. 4 No. 4 (1992): Vol 4 Issue 4
Abstract
Phenyl-, p-tolyl and p-chlorophenyl benzyl ketone condense with dimetyl-β,β-dimethylglutarate in the presence of sodium hydride to give the corresponding half-esters, the (Z)-isomers 2a-e being predominant. The structure and configuration of the half-esters were characterized by chemical and spectroscopic evidence.
Keywords
Condensation
Aryl Benzyl Ketones
Dimetyl-β,β-dimethylglutarate
Synthesis
(Z)- and (E)-5-aryl- 4-Carbomethoxy-3,3-Dimethyl-6-Phenyl-hex-4-Enoic Acids
Abdel-Aziz El-Bassiouny, F. (2010). Condensation of Aryl Benzyl Ketones with Dimethyl-β,β- Dimethyl-Glutarate. Synthesis of (Z)- and (E)-5-aryl- 4-Carbomethoxy-3,3-Dimethyl-6-Phenyl-hex-4-Enoic Acids . Asian Journal of Chemistry, 4(4), 844–851. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/25161
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX