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Vol. 32 No. 3 (2020): Vol 32 Issue 3

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Novel Fluorinated Imidazolium Ionic Liquids: Eco-friendly, Facile and Efficient Construction, Characterization, in vitro Anticancer Activity, Toxicity and in silico Analysis

https://doi.org/10.14233/ajchem.2020.22491
Ahmed H. Albalawi
Department of Chemistry, Taibah University, 30002, Al-Madina Al-Mounawara, Saudi Arabia
Saud M. Almutairi
King Abdulaziz City for Science and Technology, Riyadh 11442, P.O. Box 6086, Saudi Arabia
Ateyatallah Aljuhani
Department of Chemistry, Taibah University, 30002, Al-Madina Al-Mounawara, Saudi Arabia
Pramod K. Sahu
School of Study in Chemistry, Jiwaji University, Gwalior-474011, India
Praveen K. Sahu
Department of Industrial Chemsitry, Jiwaji University, Gwalior-474011, India
Nadjet Rezki
Department of Chemistry, Taibah University, 30002, Al-Madina Al-Mounawara, Saudi Arabia
Mohamed R. Aouad
Department of Chemistry, Taibah University, 30002, Al-Madina Al-Mounawara, Saudi Arabia
Mouslim Messali
Department of Chemistry, Taibah University, 30002, Al-Madina Al-Mounawara, Saudi Arabia

Corresponding Author(s) : Mouslim Messali

mouslim@mail.be

Asian Journal of Chemistry, Vol. 32 No. 3 (2020): Vol 32 Issue 3

Abstract

An efficient and facile synthesis of novel fluorinated imidazolium-tagged ionic liquids under microwave irradiation is described. Novel prepared ionic liquids was identified and confirmed by spectroscopic and elemental analysis. Synthesized ionic liquids (1-12) was explored for their antiproliferative inhibition potency against three selected human cancer cell lines (MCF-7, HepG-2 and CACO2). Screening results have revealed that some tested ionic liquids exhibited promising activity compared with standard drugs, especially compounds 5 and 6 which consistently produced low IC50 values. Preliminary structure activity relationship (SAR) studies have been performed to identify the relation between molecular structure and activity. in silico Analysis of ionic liquids was carried out based on ADME, Lipinski rule, drug likeness, toxicity profiles and other physico-chemical properties. All compounds were safe in toxicity profile and computed LD50 values were in accepted range (2.55-2.89 mol/kg). in silico Results have shown that Lipinski rule of five was in accept range, except compound 1 and 2.

Keywords

Microwave conditions Ionic liquids Environmental Benign method Antitumor activity in silico Prediction
Albalawi, A. H., Almutairi, S. M., Aljuhani, A., Sahu, P. K., Sahu, P. K., Rezki, N., … Messali, M. (2020). Novel Fluorinated Imidazolium Ionic Liquids: Eco-friendly, Facile and Efficient Construction, Characterization, in vitro Anticancer Activity, Toxicity and in silico Analysis. Asian Journal of Chemistry, 32(3), 690–396. https://doi.org/10.14233/ajchem.2020.22491
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