Synthesis and Biological Activities of Some New Pyrimidine Derivatives

M. Seada; A.M. Abdel-Halim; S.S. Irbahim; M. Abdel-Megid

Issue

Vol. 4 No. 3 (1992): Vol 4 Issue 3

Issue Published : 17 July 1992

Synthesis and Biological Activities of Some New Pyrimidine Derivatives

M. Seada

Chemistry Department, Faculty of Education Ain Shams University, Roxy, Cairo, Egypt

A.M. Abdel-Halim

Chemistry Department, Faculty of Education Ain Shams University, Roxy, Cairo, Egypt

S.S. Irbahim

Chemistry Department, Faculty of Education Ain Shams University, Roxy, Cairo, Egypt

M. Abdel-Megid

Chemistry Department, Faculty of Education Ain Shams University, Roxy, Cairo, Egypt

Corresponding Author(s) : M. Seada

Asian Journal of Chemistry, Vol. 4 No. 3 (1992): Vol 4 Issue 3
Article Published : 30 March 2010

Abstract

Synthesis of 4-chloro-5-cyano-2-methyl-6-phenylpyrimidine (Ib) and its reactions with acetamidine hydrochloride, guanidine hydrochloride, cyanoacetamide, benzilmonohydrazone, sodium azide, semicarbazide hydrochloride, acidhydrazides, active methylene compounds, aromatic amines and thiourea have been investigated. Also, the reactions of 5-cyano-2-methyl-6-phenyl-4 (3H)-pyrimidinethione (IXf) with ethyl iodide, ethyl chloroacetate, phenacyl bromide, acrylonitrile and chloroheterocycle systems were reported.

Keywords

Synthesis Biological Activity Pyrimidine Derivative

(1)

Seada, M.; Abdel-Halim, A.; Irbahim, S.; Abdel-Megid, M. Synthesis and Biological Activities of Some New Pyrimidine Derivatives . ajc 2010, 4, 544-552.

Issue

Vol. 4 No. 3 (1992): Vol 4 Issue 3

Synthesis and Biological Activities of Some New Pyrimidine Derivatives

Corresponding Author(s) : M. Seada

Abstract

Keywords

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